Registration Dossier
Registration Dossier
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EC number: 945-327-8 | CAS number: -
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Synthetic amorphous silica was used, tradename Ultrasil VN3
Test solutions
- Vehicle:
- yes
- Remarks:
- SAS in suspension
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- ca. 1 000 - ca. 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- not determinable
- Remarks:
- no mortality was observed
- Details on results:
- No mortality was observed for the fish after 96 hours of exposure at 1000 mg/l and 10 000 mg/l
Applicant's summary and conclusion
- Conclusions:
- The zebra fish (Brachydanio rerio) test was performed with SAS (Ultrasil VN3, precipitated silica) in suspension, due to the insolubility of the SAS. No mortality was observed for the fish after 96 hours of exposure at 1,000 mg/l and 10,000 mg/l. The test media remained turbid throughout the test, indicating that the limit of solubility of the product was exceeded. The actual concentrations were not determined.
LC0 (96 h) approx. 10 000 mg/L. - Executive summary:
The zebra fish (Brachydanio rerio) test was performed with SAS (Ultrasil VN3, precipitated silica) in suspension, due to the insolubility of the SAS. No mortality was observed for the fish after 96 hours of exposure at 1,000 mg/l and 10,000 mg/l. The test media remained turbid throughout the test, indicating that the limit of solubility of the product was exceeded. The actual concentrations were not determined.
LC0 (96 h) approx. 10 000 mg/L.
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