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EC number: 225-190-4 | CAS number: 4706-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short term toxicity to aquatic invertebrates:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for 4706 -78 -9 (Potassium dodecyl sulfate). The EC50 value was estimated to be 164.22mg/l when Potassium dodecyl sulfate exposed to Daphnia magna for 48hrs.
Toxicity to aquatic algae and cyanobacteria:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the eight closest read across substances, toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for4706 -78 -9 (Potassium dodecyl sulfate).The EC50 value was estimated to be 130.39 mg/l when Potassium dodecyl sulfate exposed to Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) for 72hrs.
Additional information
Short term toxicity to aquatic invertebrates:
Based on the various experimental data and prediction data for the target chemical and read across chemicals have been reviewed to determine the toxic nature of target chemical Potassium dodecyl sulfate (4706-78-9). The studies are as mentioned below:
In the first weight of evidence study according to the QSAR toolbox for 4706-78-9, based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for 4706 -78 -9 (Potassium dodecyl sulfate). The EC50 value was estimated to be 164.22mg/l when Potassium dodecyl sulfate exposed to Daphnia magna for 48hrs.
In another weight of evidence study for read across chemical which support QSAR classification was Ammonium peroxydisulfate (7727-54-0), the study carried out for the determination of toxic level of chemical Ammonium peroxydisulfate. Daphnia magna taken as a test organism in the study. Test chemical expose with the 5 daphnia magna for 48hrs by performing static method. Based on mortality of the test organism daphnia magna by test chemical Ammonium peroxydisulfate, the EC50 was (101mg/l) 101000ug/l.
In the third weight of evidence study for second RA chemical was ferrous sulphate (7727-78-7) from ecotox databases, 2017. Evaluation of short term toxicity of Ferrous sulfate on the growth of daphnia magna for 16 hrs. Daphnia magna taken as a test organism. Static method was performed. Based on the immobilization of daphnia magna by the ferrous sulphate the 16hrs NOEC value was 152 mg/l. Based on the NOEC concentration Ferrous sulfate consider as non-toxic to daphnia magna and consider as not classified as per mention in CLP classification criteria.
Similarly in the another weight of evidence study for read across chemical which support QSAR classification was Ammonium peroxydisulfate (7727-54-0) from SIDS report 2005. Evaluation of toxic nature of ammonium persulphate on the growth of Daphnia magna. <24 hours ages of daphnia magna was used under the static method. The 95% confidence interval was (103-139 mg/L).Test solutions were prepared from a stock solution of 10 g ammonium persulfate/L in filtered, deionized, well water. Immobilization and some abnormal behavior was observed because of exposure of chemical with daphnia magna. Based on the immobilization of daphnia magna by the ammonium persulphate, the EC50 value was 120 mg/l. Based on the EC50 value ammonium persulphate was nontoxic and it is consider as not classified as per the CLP classification criteria.
Based on the data obtain from various databases ecotox, QSAR toolbox version 3.3, SIDS report for target and RA chemicals Potassium dodecyl sulfate (4706-78-9) was not toxic to the daphnia magna and it was consider as not classified as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria:
Based on the various experimental data and prediction data for the target chemical and read across chemicals have been reviewed to determine the toxic nature of target chemical Potassium dodecyl sulfate (4706-78-9) on the growth of algae. The studies are as mentioned below:
In the first weight of evidence study according to the QSAR toolbox for Potassium dodecyl sulfate (4706-78-9), Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the eight closest read across substances, toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for 4706 -78 -9 (Potassium dodecyl sulfate).The EC50 value was estimated to be 130.39 mg/l when Potassium dodecyl sulfate exposed to Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) for 72hrs.
In another weight of evidence study for read across chemical which support QSAR classification was decane (124-18-5) from ecotox 2017, Evaluation of short term toxicity of decane on the growth of Skeletonema costatumon for 96 hrs. Based on growth inhibition of Chlorophyll A concentration of Skeletonema costatum by the exposure of decane the EC50 was 500mg/l. Based on the EC50 value chemical consider as nontoxic to diatoms and consider as not classified as per the CLP classification criteria.
Based on the data obtain from various databases ecotox, QSAR toolbox version 3.3 for target chemicals Potassium dodecyl sulfate (4706-78-9) and RA chemical decane (124-18-5), Potassium dodecyl sulfate (4706-78-9) was not toxic to the daphnia magna and it was consider as not classified as per the CLP classification criteria.
Based on the data available for toxicity to aquatic invertebrates and algae from various sources, Potassium dodecyl sulfate (4706-78-9) was not toxic and it was consider as not classified as per the CLP classification criteria.
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