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EC number: 238-744-5 | CAS number: 14694-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-04-28 to 1998-05-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD) and to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris(triphenylphosphine)rhodium (I) chloride
- EC Number:
- 238-744-5
- EC Name:
- Tris(triphenylphosphine)rhodium (I) chloride
- Cas Number:
- 14694-95-2
- Molecular formula:
- C54H45ClP3Rh
- IUPAC Name:
- tris(triphenylphosphine)rhodium (I) chloride
- Details on test material:
- - Name of test material (as cited in study report): Chlorotris-(triphenylphosphine)-rhodium(I)
- Physical state: red, crystalline solid
- Analytical purity: Not indicated by sponsor
- Isomers composition: no data
- Lot/batch No.: Not indicated by sponsor
- Stability under test conditions: “the test substance was stable throughout the experimental period”
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White Russian (albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ASTA Pharma AG, D-4800, Bielefeld 14
- Age at study initiation: 4-6 months
- Weight at study initiation: 2.0-2.7 kg
- Housing: ASTA Model stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5-22.5
- Humidity (%): 40-65
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.3 ml - Duration of treatment / exposure:
- Single 4 hour exposure
- Observation period:
- 6 days
- Number of animals:
- 3 (2 males and 1 female)
- Details on study design:
- TEST SITE
- Type of wrap if used: The site of application was covered with a linen cloth (about 6.25 cm2) which adhered to a synthetic film glue. The opposite area of the dorsal skin was treated in the same way but without administration of the test material (control site). A bandage wrapped several times around the trunk provided complete occlusion.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: Patches removed after 4 hours.
SCORING SYSTEM: The treated skin area was qualitatively and quantitatively scored using the Draize method at 1, 24, 48, and 72 hrs, and thereafter daily, following removal of the patches (see OECD guidelines for grading of skin reactions). The individual values for erythema/eschar formation and oedema at the 1, 24, 48, and 72-hr readings were added separately and divided by 12. The primary irritation index is given by the sum of these two mean values.
The following gradation was allocated to this index by a modified method from Gilman et al. (1983):
Primary irritation index Gradation
0.0-0.5 non-irritant
0.6-3.0 slight irritant
3.1-5.0 moderate irritant
5.1-8.0 severe irritant
In addition, attention was paid to the occurrence of other skin reactions and irreversible alteration of the dermal tissue (which would lead to a classification of corrosive effects) and systemic toxic effects.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- ca. 0.9
- Max. score:
- 8
- Reversibility:
- fully reversible within: 6 days for erythema
- Remarks on result:
- other: Very slight erythema seen in all animals. No eschar formation or oedema seen.
- Irritant / corrosive response data:
- Very slight erythema (barely perceptible) (a score of 1) was noted in all three rabbits assessed at 24, 48 and 72 hr after patch removal, in two rabbits assed after 1 hr, and in two rabbits assessed 4 days after patch removal.
- Other effects:
- One animal reacted with skin scales, which immediately peeled off. After removal of the patch, brownish colouration of the application site was noted in one animal. No systemic-toxic effects were seen and the general condition of the test animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline study, to GLP, chlorotris-(triphenylphosphine)-rhodium(I) was applied to the intact skin of three rabbits (4-hr occluded) and irritant reactions were assessed 1, 24, 48, and 72-hr after patch removal. The test item produced an overall primary irritation index of 0.9 (very slight but reversible erythema observed in all animals). No eschar formation, oedema, or systemic toxicity was apparent.
- Executive summary:
In an OECD Test Guideline 404 study, conducted according to GLP, chlorotris-(triphenylphosphine)-rhodium(I) was investigated for irritant (and corrosive) effects following its 4-hr (occluded) application (0.5 g) to the intact dorsal skin of three White Russian rabbits (two males and one female). The test sites were observed for signs of erythema/eschar formation and oedema using the Draize grading scores, at 1 hr, and then daily for up to six days, after patch removal. The opposite area of the dorsal skin was treated in the same way, but without application of the test substance (control site).
Very slight erythema (a score of 1) was noted in all animals assessed at 24, 48 and 72-hrs after patch removal, in two rabbits assed after 1 hr, and in two rabbits assessed 4-days after patch removal. No such findings were seen from day 6 of observation. No eschar formation or oedema was seen in any animal. One rabbit reacted with skin scales, which immediately peeled off. Brownish colouration of the application site was noted in one animal. No systemic-toxic effects were seen and the general condition of the test animals was not affected.
Based on the results of this study, no classification for skin irritation is required according to EU CLP criteria (EC 1272/2008).
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