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Diss Factsheets
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EC number: 215-925-7 | CAS number: 1453-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-08-18 - 2008-10-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffer pH 4:
10.2 g of Potassium hydrogen phthalate were weighed into a 1000 mL volumetric flask and Potassium hydrogen phthalate was dissolved in ca 800 mL water. After this step, 4 mL of 0.1M NaOH were added and the volumetric flask was filled up to its volume with water. pH = 4.00 (23.3 °C)
Buffer pH 7:
6.8 g of KH2PO4 were weighed into a 1000 mL volumetric flask and KH2PO4 was dissolved in ca 800 mL water. After this step, 296 mL of 0.1M NaOH were added and the volumetric flask was filled up to its volume with water.
pH = 7.00 (25.0 °C)
Buffer pH 9:
3.09 g of H3BO3 and 3.73 g of KC1 were weighed into a 1000 mL volumetric flask and substances were dissolved in ca 800 mL water. After this step, 213 mL of 0.1 M NaOH were added and the volumetric flask was filled up to its volume with water.
pH = 8.99 (25.0 °C) - Duration:
- 5 d
- pH:
- 4
- Initial conc. measured:
- 9.37 - 9.54 mg/L
- Duration:
- 5 d
- pH:
- 7
- Initial conc. measured:
- 10.55 - 10.72 mg/L
- Duration:
- 5 d
- pH:
- 9
- Initial conc. measured:
- 10.18 mg/L
- Number of replicates:
- 2
- Transformation products:
- not measured
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The preliminary testing performed at 50 ± 0.5 °C at three pH values: 4, 7 and 9 shows, that less than 10 % of the test substance was hydrolysed within 5-day period. According to the test guideline recommendation (Chapter 1.6.5.1. Preliminary test) the half-life time of hydrolysis can therefore be expected to be greater than one year at 25°C and no further testing is required.
- Executive summary:
Hydrolysis as a function of pH of the test substance, 3-Methylpyrazol, was studied. The procedure was performed according to: Method C.7 - Degradation - Abiotic Degradation Hydrolysis as a Function of pH, Directive 92/69/EEC. Published in OJ No L 383 A, December 1992. The preliminary testing performed at 50 ± 0.5 °C at three pH values: 4, 7 and 9 shows, that less than 10 % of the test substance was hydrolysed within 5-day period. According to the test guideline recommendation the half-life time of hydrolysis can therefore be expected to be greater than one year at 25°C and no further testing is required.
Reference
Description of key information
The half-life for hydrolysis of 3-Methylpyrazole is greater than 1 year.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The preliminary testing performed at 50 ± 0.5 °C at three pH values: 4, 7 and 9 shows, that less than 10 % of the test substance was hydrolysed within 5-day period. According to the test guideline recommendation the half-life time of hydrolysis can therefore be expected to be greater than one year at 25°C and no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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