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Diss Factsheets
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EC number: 202-411-2 | CAS number: 95-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- embryonic mortality, mutagens
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable test system, incomplete and inexact data on study design.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Vulcanization accelerators on embryonic mortality in rats
- Author:
- Aleksandrov, S.E.:
- Year:
- 1 982
- Bibliographic source:
- Bull. Exp. Biol. Med. 93, 87-88
Materials and methods
- Principles of method if other than guideline:
- Rats were applied Santocure (N-cyclohexylbenzothiazole-2-sulphenamide) before or during pregnancy to determine the primary mechanism of embryonic mortality (mutagenic action on gametes at the beginning of embryogenesis, toxic action of the chemical on the embryo or hormonal disturbances in the mother).
- GLP compliance:
- no
- Type of assay:
- other: embryonic mortality
Test material
- Reference substance name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- EC Number:
- 202-411-2
- EC Name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- Cas Number:
- 95-33-0
- Molecular formula:
- C13H16N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
- Test material form:
- solid: particulate/powder
- Remarks:
- Beige
- Details on test material:
- Test substance: Santocure CBS
- Analytical purity: 96.2 %
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- Females: twice (1st, 3rd day of oestrus), males (interval of 3 days)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 10 females treatment group, control: 25 females
Results and discussion
Test results
- Sex:
- male/female
Any other information on results incl. tables
No increased postimplantation embryonic mortality (= "index of mutagenicity").
Applicant's summary and conclusion
- Executive summary:
Rats were applied Santocure (N-cyclohexylbenzothiazole-2-sulphenamide) before or during pregnancy to determine the primary mechanism of embryonic mortality (mutagenic action on gametes at the beginning of embryogenesis, toxic action of the chemical on the embryo or hormonal disturbances in the mother). On the basis of these experimental results it was not possible to determine precisely which mechanism caused the rise in embryonic mortality and the decrease in weight of the fetuses.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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