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Diss Factsheets
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EC number: 202-411-2 | CAS number: 95-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable documented study report, which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
- Title:
- Acute toxicologic evaluation of Santocure vulcanization accelerator
- Author:
- Randall, D.J. and Bannister, R.M.,
- Year:
- 1 990
- Bibliographic source:
- Acute Toxic. Data 1 (2), 105-106
Materials and methods
- Principles of method if other than guideline:
- The acute oral toxicity of CBS was evaluated in an acceptable documented study with Sprague-Dawley Albino rats. A 25 % solution-suspension of CBS in corn oil was administered by gavage to 4 groups of 5 Sprague-Dawley albino rats at doses of 3980, 5010, 6310 and 7940 mg/kg bw. A 7-day observation period followed administration.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- EC Number:
- 202-411-2
- EC Name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- Cas Number:
- 95-33-0
- Molecular formula:
- C13H16N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
- Details on test material:
- IUCLID4 Test substance: other TS: as prescribed by chapter 1 in dataset of Monsanto
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 3980, 5010, 6310, 7940 mg/kg bw
- No. of animals per sex per dose:
- 5 per dose group (mixed males and females; 2-3 males per group, 2-3 females per group).
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Signs of Intoxication: Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death Gross autopsy: lung and liver hyperemia and acute gastrointestinal inflammation.
- Mortality:
- 3980 mg/kg bw: 0/5 animals died; 5010 mg/kg bw: 1/5 animals died; 6310 mg/kg bw: 4/5 animals died; 7940 mg/kg bw: 4/5 animals died.
- Clinical signs:
- other: Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death.
- Gross pathology:
- Decendents: lung and liver hyperemia and acute gastrointestinal inflammation.
Survivors: Vicera of surviving animals appeared normal at sacrifice.
Any other information on results incl. tables
Signs of Intoxication: Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death.
Gross autopsy:
Decendents: lung and liver hyperemia and acute gastrointestinal inflammation.
Survivors: Vicera of surviving animals appeared normal at sacrifice.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 = 5300 mg/kg bw.
- Executive summary:
The acute oral toxicity of CBS was evaluated in an acceptable documented study with Sprague-Dawley Albino rats. A 25 % solution-suspension of CBS in corn oil was administered by gavage to t groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 3980, 5010, 6310 and 7940 mg/kg bw. A 7-day observation period followed administration. The acute oral LD50 for CBS for male and female rats was calculated to be 5300 mg/kg bw (Monsanto Co. 1973).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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