Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-342-7 | CAS number: 1163775-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4.2.2015-13.8.2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Health Care Inspectorate of Health, Welfare and Sport, Den Haag, The Netherlands
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2,4-Benzenetricarboxylic acid, mixed dodecyl and octy triesters
- IUPAC Name:
- 1,2,4-Benzenetricarboxylic acid, mixed dodecyl and octy triesters
- Reference substance name:
- tris(mixed dodecyl and octyl)benzene-1,2,4-tricarboxylate
- EC Number:
- 700-342-7
- Cas Number:
- 1163775-81-2
- Molecular formula:
- C14H47O6 to C18H55O6
- IUPAC Name:
- tris(mixed dodecyl and octyl)benzene-1,2,4-tricarboxylate
- Reference substance name:
- Linplast 812 TM
- IUPAC Name:
- Linplast 812 TM
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- N/A
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Beijing Vital Rive Laboratory Animal Technology Co., Ltd., China
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 245-268 g (males), 224-243 g (females)
- Housing: Animals were raised in suspended, stainless steel cages (32x28x20cm) on cage racks (16 7x70x171 cm). There were 10 cages per layer, and 4 layers per rack. Animals were housed individually during the test.
- Diet (e.g. ad libitum): sterilized diet with complete nutrition supplied by Beijing keaoxieli Feed Co., Ltd.
- Water (e.g. ad libitum): drinking water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.1 ± 24
- Humidity (%): 44-69
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 2015-04-30 To: 2015-05-19
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
Approximately 24 hours before the test, fur was removed from the dorsal area of the trunk of the test animals by shaving. Care was taken to avoid abrading the skin, which could alter its permeability.
Each animal was dosed once and only animals with healthy and intact skin were used.
The gauze with the test item was placed uniformly over the treatment area and semi-occluded with a piece of self-adhesive bandage. Shortly after dosing the dressing should be examined to ensure that the animals cannot ingest the test item.
- Area of exposure: dorsal surfaces of the trunk (clear area 40 cm²)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, at the end of exposure period for approximately 24 hours, residual test item was removed by cotton wool soaked in water.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Because the test item was liquid, before administration calculate the theoretical test item used for each animal in accordance with the design of dose and animal body weight. The mean density was 941 mg/L. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once in the first 30 minutes and at 1,2 and 4 hours after dosing and then once each day for up to 14 days. Observation included changes in skin and fur, eyes and mucous membranes, and also respiratory, circulatory, autonomic and central nervous systems , and somatomotor activity and behaviour pattern. Attention had been directed to observations of tr emors, convulsions, salivation, diarrhoea, lethargy, sleep and coma; bodyweights were determined on day of dosing (day 0) 7 and 14 days thereafter or at death.
- Skin irritation: Adverse skin reactions at the site of application were recorded daily following the removal of the dressings.
- Necropsy of survivors performed: yes, all animals under test, included carefully eye examinations of the abdominal, thoracic organs and their contents - Statistics:
- not performed
Results and discussion
- Preliminary study:
- N/A
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occurred
- Clinical signs:
- other: no clinical signs were observed
- Gross pathology:
- No abnormalities found.
- Other findings:
- No signs of dermal irritation.
Any other information on results incl. tables
N/A
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results, the acute dermal LD50 in rats for 1,2,4-Benzenetricarboxylic Acid, mixed dodecyl and octyl triesters for male rats was > 2000 mg/kg and for female rats also > 2000 mg/kg.
- Executive summary:
The study was performed to assess the acute dermal toxicity of 1,2,4 -Benzenetricarboxylic acid, mixed dodecyl and octyl triesters in Sprague Dawley rats according to OECD 402. At test at one dose level of 2000 mg/kg bw was carried out in a group of 10 animals (5 males and 5 females). Clinical observations were made during the first 30 minutes, and at 1,2, and 4 hours after dosing and then once each day for up to 14 days. Individual weights of animals were determined at grouping, day 0 (day of dosing), on day 7 and 14. At the end of the test, a gross necroscopy was performed on all animals under test. There were not deaths of moribund during the test. There were no abnormal findings in all animals after dosing from the first day until the end of the test. There were no signs of dermal irritation. One animal showed a small decrease in body weight during the second week.
Based on the results, the acute dermal LD50 in rats for 1,2,4-Benzenetricarboxylic Acid, mixed dodecyl and octyl triesters for male rats was > 2000 mg/kg and for female rats also > 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.