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Diss Factsheets
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EC number: 500-537-5 | CAS number: 161075-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Auto flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- auto-ignition temperature (liquids)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental result obtained on substance with similar chemical structure, according to recognized international standard method.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis is that, basing on the structural similarity, experimental data on H-GALDEN can be used in order to get information on the biological behaviour of GALDEN LMW and on certain type of physical-chemical properties. Basing on available data, the source is anticipated to be a worst-case.
The hyphotesis is developed further in the attached "The Read-Across Justification Document".
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Target = GALDEN LMW // Source = H-GALDEN
Information on identity, purity and impurities of target and source chemicals is detailed in the attached "The Read-Across Justification Document".
3. ANALOGUE APPROACH JUSTIFICATION
The approach is justified by the structure similarity between GALDEN LMW and H-GALDEN which are both fluoroethers and characterized by the presence of the C-F bond in their entire carbon chains with the exception of the terminal groups in H-GALDEN.
Both the C-F and ether bonds participate in giving the fluoroethers their typical properties in term of thermal and chemical stability but the C-F bond in particular is recognized to increase the stability of the structure. As the C-F bond constitutes the main backbone of the two structures, GALDEN LMW and H-GALDEN are anticipated to have similar stability in term of ignition and thermal degradation.Both GALDEN LMW and H-GALDEN do not flash (no FP untill the BP). H-GALDEN may eventually represent a worst case for physicochemical read across due to the presence of the hydrogen atom in the terminal groups of the molecule (the bond C-H is weaker than the bond C-F) which may make H-GALDEN more sensitive to ignition and thermal degradation than GALDEN LMW.
The use of the information available on H-GALDEN for reading across to GALDEN LMW is considered justifiable becasue for the Auto-ignition temperature endpoint no study is required to be conducted on GALDEN LMW as the substance was determined to not flash until boiling. Basing on this result GALDEN LMW is recognized to be of no concern in regards of its auto-ignition properties and the test does not need to be conducted according to Column 2 adaptation. The experimental data available on H-GALDEN support the lack of concern in regards of auto-ignition up to 600°C.
The analogue approach justification is discussed in the attached "The Read-Across Justification Document".
4. DATA MATRIX
The data matrix is reported in the attached "The Read-Across Justification Document".
----------------
The Read-Across Justification Document is attatched. It is developed according to Read-Across Assessment Framework (RAAF) (ECHA, 2017) and the complementary guidance on considerations on multi-constituent substances and UVCBs (ECHA, 2017) - Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Key result
- Auto-ignition temperature:
- > 600 °C
- Atm. press.:
- 1 010 mBar
- Remarks on result:
- not determinable
- Remarks:
- no autoignition up to the temperature of 600°C
- Conclusions:
- Based on Read Across with H-GALDEN, it can be affirm that GALDEN LMW shows no self ignition until the temperature of 600 °C.
- Executive summary:
The analogue substance H-GALDEN was tested for auto-ignition temperature according to ASTM method No. E 659.
H-GALDEN is a hydrofluoropolyether with similar chain structure and similar molecular weight of GALDEN LMW. The differences between the two substances are the monomer units (the monomer unit in H-GALDEN is (C2F4O) while the monomer unit of GALDEN LMW is (C3F6O) ) and the presence of a single hydrogen atom segregated in the terminal groups of the molecule H-GALDEN.
Basing on the structural similarity, experimental data on H-GALDEN can be used in order to get information on phisico-chemical properties and biological behaviour of GALDEN LMW. It should be noted that the presence of –OCF2H as terminal groups in H-GALDEN, gives to the product slight more reactivity and more polarity than those observed for GALDEN, characterised by neutral, non functional terminal groups –OCF3.
H GALDEN, tested until the temperature of 600 °C under a pressure of 1010 mbar (101000 Pa), showed no autoignition.
Because of the presence of –OCF2H as terminal groups in H GALDEN, which gives to the product more reactivity and more polarity than those observed for GALDEN LMW, the reported read across represents a worst case approach and therefore in conclusion, it can be affirm that GALDEN LMW shows no self ignition until the temperature of 600 °C and under a pressure of 101000 Pa.
- Endpoint:
- auto-ignition temperature (liquids)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a liquid non flammable in air, e.g. no flash point up to 200°C
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
GALDEN LMW was tested for flash point and fire point determination according to the method ASTM D92 "Standard Test Method for Flash and Fire Points by Cleveland Open Cup Tester” and no flash point and fire point were observed up to the boiling of the test item. GALDEN LMW is therefore a non flammable liquid in air and the auto-ignition test does not need to be conducted.
In addition, as supporting information of absence of auto-ignition, an auto-ignition temperature determination on the analogue substance H GALDEN is reported. The analogue substance H-GALDEN was tested for auto-ignition temperature according to ASTM method No. E 659.
H-GALDEN is a hydrofluoropolyether with similar chain structure and similar molecular weight of GALDEN LMW. The differences between the two substances are the monomer units (the monomer unit in H-GALDEN is (C2F4O) while the monomer unit of GALDEN LMW is (C3F6O) ) and the presence of a single hydrogen atom segregated in the terminal groups of the molecule H-GALDEN. Basing on the structural similarity, experimental data on H-GALDEN can be used in order to get information on physico-chemical properties and the biological behaviour of GALDEN LMW. Moreover, because of the presence of –OCF2H as terminal groups in H-GALDEN, H-GALDEN is more reactive GALDEN LMW which is characterised by neutral, non functional terminal groups –OCF3.
H-GALDEN, tested until the temperature of 600 °C under a pressure of 1010 mbar (101000 Pa), showed no autoignition. Because of the presence of –OCF2H as terminal groups in H GALDEN, the reported read across represents a worst case and therefore in conclusion, it can be affirm that GALDEN LMW is expected to have no auto-ignition until the temperature of 600 °C and under a pressure of 101000 Pa.
Furthermore to support the slight reactivity of GALDEN LMW for self-ignition, the results of a self-ignition determination test conducted at constant temperature and variable oxygen pressure on several products of GALDEN and FOMBLIN families are reported. The test was conducted by a German recognized organization with the purpose to certify materials for the safe use in plants on contact with Oxygen.
GALDEN and FOMBLIN products have the same chemical structure and the only difference is the molecular weight, therefore they can be grouped in the same category. Since the molecular structure is the same, the physical properties depending from molecular weight follow a trend across the category whereas physical properties depending only from the arrangement of chemical structure and from presence/absence of functional groups are the same for the all category members. Experimental results confirm slight reactivity on contact with oxygen of all the members of GALDEN-FOMBLIN category tested.
Since the molecular structure is the same, the same slight reactivity concerning reaction with oxygen is expected for GALDEN LMW.
Referenceopen allclose all
Description of key information
GALDEN LMW is a non flammable liquid in air and the auto-ignition test does not need to be conducted.
In addition, basing on data available on analogue compound GALDEN LMW is not expected to have auto-ignition until the temperature of 600°C at atmospheric pressure.
Key value for chemical safety assessment
Additional information
According to Column 2 of REACH Annex VII the test does not need to be conducted for liquids non flammable in air.
GALDEN LMW was tested for flash point and fire point determination according to the method ASTM D92 "Standard Test Method for Flash and Fire Points by Cleveland Open Cup Tester” and no flash point and fire point were observed up to the boiling of the test item. GALDEN LMW is therefore a non flammable liquid in air and the auto-ignition test does not need to be conducted.
In addition, as supporting information of absence of auto-ignition, an auto-ignition temperature determination on the analogue substance H GALDEN is reported. The analogue substance H-GALDEN was tested for auto-ignition temperature according to ASTM method No. E 659.
H-GALDEN is a hydrofluoropolyether with similar chain structure and similar molecular weight of GALDEN LMW. The differences between the two substances are the monomer units (the monomer unit in H-GALDEN is (C2F4O) while the monomer unit of GALDEN LMW is (C3F6O) ) and the presence of a single hydrogen atom segregated in the terminal groups of the molecule H-GALDEN. Basing on the structural similarity, experimental data on H-GALDEN can be used in order to get information on physico-chemical properties and the biological behaviour of GALDEN LMW. Moreover, because of the presence of –OCF2H as terminal groups in H-GALDEN, H-GALDEN is more reactive GALDEN LMW which is characterised by neutral, non functional terminal groups –OCF3.
H-GALDEN, tested until the temperature of 600 °C under a pressure of 1010 mbar (101000 Pa), showed no autoignition. Because of the presence of –OCF2H as terminal groups in H GALDEN, the reported read across represents a worst case and therefore in conclusion, it can be affirm that GALDEN LMW is expected to have no auto-ignition until the temperature of 600 °C and under a pressure of 101000 Pa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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