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EC number: 240-827-6 | CAS number: 16774-21-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- from 5 March 2013 to 18 June 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Diammonium hexanitratocerate
- EC Number:
- 240-827-6
- EC Name:
- Diammonium hexanitratocerate
- Cas Number:
- 16774-21-3
- Molecular formula:
- CeN6O18.2H4N
- IUPAC Name:
- diammonium cerium(IV) nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name as mentioned in the study report: cerium ammonium nitrate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Leicestershire, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.6 kg
- Housing: suspended cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23°C
- Humidity (%): 30-70%
- Air changes (per hr): at least 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12h light (6-18h); 12h dark (18-6h)
IN-LIFE DATES: From: 5 March 2013 To: 5 March 2013
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: not needed
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test item was used as supplied, moistened sufficiently with 0.5 mL of distilled water to achieve a paste. - Duration of treatment / exposure:
- 3 minutes
1 hour
4 hours - Observation period:
- immediately after removal and approximately 1h later
- Number of animals:
- one male
- Details on study design:
- TEST SITE
- Area of exposure: 3 suitable sites on the back of the rabbit
- Type of wrap if used: 2.5 cm x 2.5 cm cotton gauze patch, secured with a strip of surgical adhesive tape. The trunk was wrapped in an elasticated corset for the duration of the exposure period.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test item was removed by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: immediately
SCORING SYSTEM:
Erythema and eschar formation:
No erythema - 0
Very slight erythema (barely perceptible) - 1
Well-defined erythema - 2
Moderate to severe erythema - 3
Severe erythema (beff redness) to eschar formation preventing grading of erythema - 4
Edema formation:
No edema - 0
Very slight edema (barely perceptible) - 1
Slight edema (edges of area well defined by definite raising) - 2
Moderate edema (raised approximately 1 millimeter) - 3
Severe edema (raised more than 1 millimeter extending beyond the area of exposure) - 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- 3 min exposure
- Basis:
- animal #1
- Time point:
- other: immediately and 1 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Remarks:
- 1 hour exposure
- Basis:
- animal #1
- Time point:
- other: immediately and 1 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Remarks:
- 4 hour exposure
- Basis:
- animal #1
- Time point:
- other: immediately
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: purple/green colored dermal necrosis, animal was killed for humane reasons after the observation
- Irritation parameter:
- edema score
- Remarks:
- 4 hour exposure
- Basis:
- animal #1
- Time point:
- other: immediately
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: animal killed for humane reasons after the observation
- Irritant / corrosive response data:
- 3-Minute and 1-Hour semi-occluded applications of the test item to the intact skin of one rabbit produced no evidence of skin irritation.
A single 4-Hour semi-occluded application of the test item to the intact skin of one rabbit produced: Well-defined erythema and slight oedema were noted at the test site immediately after patch removal. Purple/green colored dermal necrosis, approximately 2 cm x 2 cm in size and extending approximately 1 cm below and 1 cm to the rear of the test site, was also noted at the observation.
The skin reactions noted were considered to be irreversible and indicative of full thickness tissue destruction, therefore the animal was killed for humane reasons immediately after the observation, in accordance with Company policy and current UK Home Office guidelines.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The test item was classified as corrosive to rabbit skin (based on one animal only). The test item was classified as Category 1C according to the CLP Regulation 1272/2008.
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