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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1956
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The study was well documented and meets generally accepted scientific principles, but did not follow current guideline requirements, pre-dates GLP and cannot be used for classification. It does, however, add weight of evidence for the acute toxicity of 3-(triethoxysilyl)propiononitrile.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report date:
1956

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Female rats were exposed to substantially saturated vapour of 3-(triethoxysilyl)propiononitrile for a period of 8 hours. Non-guideline study that pre-dates GLP
GLP compliance:
no
Test type:
other: exposure to substantially saturated vapour
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(triethoxysilyl)propiononitrile
EC Number:
213-050-5
EC Name:
3-(triethoxysilyl)propiononitrile
Cas Number:
919-31-3
Molecular formula:
C9H19NO3Si
IUPAC Name:
3-(triethoxysilyl)propanenitrile

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
No data available.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION:

Concentrated vapour was generated at room temperature by passing air at 2.5 litres/minute through a fritted glass  disc immersed in  50 ml of 3-(triethoxysilyl)propiononitrile.





Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
Substantially saturated vapour. Analytical concentration not determined.
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Statistics:
No data available.

Results and discussion

Preliminary study:
Concentrations were not measured. One of six rats died.
Mortality:
One out of 6 rats died in response to the exposure.
Clinical signs:
other: No data available.
Body weight:
No data available.
Gross pathology:
No data available.
Other findings:
No data available.

Any other information on results incl. tables

Inhalation exposure to concentrated vapor generated at room temperature caused the death of 1 of 6 adult female rats.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
In a non-guideline study, which pre-dates GLP, exposure of female rats to substantially saturated vapour of 3-(triethoxysilyl)propiononitrile (concentrations not specified) for 8 hours, resulted in the death of one out of six test animals. This study is assigned reliability 4 and cannot be used for classification. It does, however, add weight of evidence for the acute toxicity of 3-(triethoxysilyl)propiononitrile.