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EC number: 468-880-2 | CAS number: 102985-93-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-11-18 to 2005-08-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- adopted 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- adopted 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling preparation:
Aqueous samples (10.0 mL) were membrane filtrated (Nylon, 0.45 μm). The filtrate was acidified with 2M-HCl to pH 2 – 3. 10.0 mL of the filtrate were given on the top of a column with 5.0 g Extrelute. After 30 minutes, elution was slowly performed with ethyl acetate (50 mL, 30 minutes), the eluate wasrotated down to dryness and 500 μL ISTD-solution were added. At last, 400 μL of the solution were mixed with 50 resp. 100 μL SIL -Mix in vials, and silylation was performed at 80 °C for 60 minutes. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
1. Experiment:
- Method: As the test item is poorly water soluble, the “water-accommodated fraction” was tested. This was done by weighing the nominal load 100 mg/L, adding the corresponding amount of dilution water and shaking vigorously for 24 hours. As it was not possible to filtrate or centrifugate the resulting solution the test was performed with the unfiltrated emulsion.
- Differential loading: 100 mg/L nominal load
- Controls: one vessel
2. Experiment:
- Method: A stock solution containing 10 g/L in acetone was prepared. On each day of the test, the treatments 0.1 and 1 mg/L were prepared by spiking the corresponding amount of dilution water with this stock solution
- Differential loading: 0.1 / 1 mg/L
- Controls: one vessel
3. Experiment:
- Method: A stock solution containing 10 g/L in acetone was prepared. On each day of the test, the treatment 1 mg/L was prepared by spiking the corresponding amount of dilution water with this stock solution.
- Differential loading: 0.1 / 1 mg/L
- Controls: one vessel - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Danio rerio
- Source: Weiler´s Pet´s best, Turmstr. 6, 67433 Neustadt
- Length at study initiation (length definition, mean, range and SD): 2 ± 1 cm
- Amount: totalling to about 1-2% of body weight per day
- Frequency: three times a day
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test conditions
- Health during acclimation: no mortality observed - Test type:
- other: 1.Experiment: static; 2 and 3. Experiment: semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 1. 22.8 – 23.0 °C
2. 22.0 – 22.4 °C
3. 22.0 – 23.0 °C - pH:
- 1. 7.9 to 8.2
2. 8.0 to 8.2
3. 7.9 to 8.1 - Dissolved oxygen:
- above 8.3 mg/L
- Nominal and measured concentrations:
- 100, 1, 0.1 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria, maximal volume 10 L
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel:
1. Experiment:
7 L test solution and 7 fish
2. Experiment:
3 L test solution and 3 fish
3. Experiment:
7 L test solution and 7 fish
- No. of vessels per concentration: one vessel
- No. of vessels per control: one vessel
- No. of vessels per vehicle control: one vessel
- Biomass loading rate: 1 fish/L
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 12/12 hours using neon tubes - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- 1. Experiment:
The fish were found dead after 48 hours. During the shaking period for the preparation of the WAF, an emulsion was produced. This emulsion couldn’t be filtrated or centrifuged. The unsolved part of the test item rose to the surface. This effect probably caused the mortality. Therefore the experiment was repeated, but the test solution was prepared by spiking with an acetone stock solution.
2. Experiment:
None of the fish died or showed any signs of morbidity during the test. Based on these results, a further experiment with analytical determination was performed. In order to ensure testing at the maximal water solubility, the treatment 1 mg/L was chosen.
3. Experiment:
A thin oily film on the surface could be observed, but none of the fish died or showed any signs of abnormality during the test. This experiment was used to determine the biological results. - Sublethal observations / clinical signs:
At the start of the test, at every medium renewal and four hours after each renewal, the content of the test item in each test solution was determined using GC. The measured concentrations of the fresh test solutions (at the start of the test and at each medium renewal after every 24 hours) were between 36 and 53 % of the nominal concentration. Sample preparation and clean-up requires about one hour. During this time, the test item already undergoes hydrolysis which probably caused the lower recoveries. The measured concentrations 4 hours after each medium renewal were between 7and 37 % of the nominal concentration. The test item is not stable in water (as has been demonstrated in the respective study “determination of water solubility”). Due to the rapid degradation, referring to determined values is not meaningful and only the nominal values were used.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 h LC50 was determined at greater than 1 mg/L and the 96 h NOEC was 1 mg/L.
- Executive summary:
The study was performed in order to evaluate the toxic potential of the product 2,2-Dimethyl-3-lauroyloxy-propanal the toxic potential of test item towards freshwater fish, using the species Danio rerio. Three experiments were performed. As the test item is poorly water soluble, the “water-accommodated fraction” was tested in the first experiment. This was done by weighing the nominal load 100 mg/L, adding the corresponding amount of dilution water and shaking vigorously for 24 hours. As it was not possible to filtrate or centrifuge the resulting emulsion, the test was performed with the unfiltered emulsion. Seven fish were exposed to the test item for 96 hours in a static test. After 48 hours, 100 % mortality was observed in the treatment, probably caused by the undissolved test item. In the control, none of the fish showed signs of morbidity at the end of the test. The pH and the oxygen values were normal. Experiments two and three were performed under semi-static conditions with medium renewal after 24 hours. For the second experiment a stock solution in acetone was prepared. The treatments 0.1 mg/L and 1 mg/L were prepared by spiking the corresponding amount of dilution water with this stock solution. The treatment concentration of 1 mg/L was above maximal water solubility of 0.227 mg/L. Three fish were exposed to the test item for 96 hours. No mortality was observed in both treatment groups and the control. Based on these experiments, the third experiment was performed as a limit-test under semistatic conditions, using a treatment concentration of 1 mg/L with an acetone-spiked test solution. Seven fish were exposed to the test item for 96 hours in a static test. None of the fish died or showed signs of toxicity during the test. The pH and the oxygen values were normal. The 96 h LC50 was determined at greater than 1 mg/L and the 96 h NOEC was 1 mg/L. These data were already submitted in a NONS dossier under Directive 92/32/EEC (notification number 05-04-1922-00 from 2005-10-25) and considered valid and uncritical from the German Competent Authority (BAUA).
Reference
Description of key information
Aldehyde L was assessed in a short-term toxicity to fish study according to EU-method C.1 and OECD guideline 203. Fish were exposed to static and semi-static conditions at a nominal concentration of 100, 1 and 0.1 mg/L. The 96 h LC50 was determined at greater than 1 mg/L and the 96 h NOEC was 1 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 1 mg/L
Additional information
The study was performed in order to evaluate the toxic potential of the product 2,2-Dimethyl-3-lauroyloxy-propanal the toxic potential of test item towards freshwater fish, using the species Danio rerio. Three experiments were performed. As the test item is poorly water soluble, the “water-accommodated fraction” was tested in the first experiment. This was done by weighing the nominal load 100 mg/L, adding the corresponding amount of dilution water and shaking vigorously for 24 hours. As it was not possible to filtrate or centrifuge the resulting emulsion, the test was performed with the unfiltered emulsion. Seven fish were exposed to the test item for 96 hours in a static test. After 48 hours, 100 % mortality was observed in the treatment, probably caused by the undissolved test item. In the control, none of the fish showed signs of morbidity at the end of the test. The pH and the oxygen values were normal. Experiments two and three were performed under semi-static conditions with medium renewal after 24 hours. For the second experiment a stock solution in acetone was prepared. The treatments 0.1 mg/L and 1 mg/L were prepared by spiking the corresponding amount of dilution water with this stock solution. The treatment concentration of 1 mg/L was above maximal water solubility of 0.227 mg/L. Three fish were exposed to the test item for 96 hours. No mortality was observed in both treatment groups and the control. Based on these experiments, the third experiment was performed as a limit-test under semistatic conditions, using a treatment concentration of 1 mg/L with an acetone-spiked test solution. Seven fish were exposed to the test item for 96 hours in a static test. None of the fish died or showed signs of toxicity during the test. The pH and the oxygen values were normal. The 96 h LC50 was determined at greater than 1 mg/L and the 96 h NOEC was 1 mg/L. These data were already submitted in a NONS dossier under Directive 92/32/EEC (notification number 05-04-1922-00 from 2005-10-25) and considered valid and uncritical from the German Competent Authority (BAUA).
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