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EC number: 695-953-8 | CAS number: 204918-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- prop-2-en-1-yl 2-(2-chloro-5-isocyanatobenzoyloxy)-2-methylpropanoate
- EC Number:
- 695-953-8
- Cas Number:
- 204918-22-9
- Molecular formula:
- C15H14ClNO5
- IUPAC Name:
- prop-2-en-1-yl 2-(2-chloro-5-isocyanatobenzoyloxy)-2-methylpropanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd. Biotechnology & Animal Breeding Division. CH-4414 Füllinsdorf / Switzerland
- Age at study initiation: 8 - 10 weeks.
- Weight at study initiation: Males: 222.1 - 236.4 g Females: 172.5 - 187.2 g.
- Housing: Groups of three.
- Diet: ad libitum (fasting for 1 hour prior to dosing and for 3 hours after dosing).
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 -24°C
- Humidity (%): 36 - 57 %
- Air changes (per hr): 10- 15 changes/hour
- Photoperiod: 12 hours light / 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- 300
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle (mg of test item/kg body weight): 200 mg/kg females, 200 mg/kg males, 2000 mg/kg females
- Amount of vehicle (if gavage): 10 ml
- Lot/batch no. (if required): 4053741/1 30600
DOSAGE PREPARATION: The prepartion was made shortly before dosing.
- Rationale: Oral administration was used as this is one possible route of human exposure during manufacture, handling and use of the test item - Doses:
- 200 mg test item/kg body weight females, 200 mg test item/kg body weight males, 2000 mg test item/kg body weight females.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- OBSERVATIONS
Mortality/Viability: One, two, three and five hours after the test item administration for the surviving animals. Twice daily during
days 2 – 15 for the surviving animals.
Body weights: On test days 1 (pre-administration), 8 and 15 for surviving animals.
Clinical signs: Each animal was examined for changes in appearance and behaviour four times during day 1, and once daily for
surviving animals during dyas 2 – 15. All abnormalities were recorded.
TERMINAL SACRIFICE
At the end of the observation period (test day 15) all surviving animals were sacrificed.
Animals which had died spontaneously during the observation were necropsied as soon as they were found dead. - Statistics:
- The toxicity was estimated without the use of a statistical model.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All male and female animals treated at 200 mg/kg survived until scheduled necropsy. All female animals treated at 2000 mg/kg were found dead, on test day 2 (2 animals), 1 on test day 3 (1 animal).
- Clinical signs:
- other: No clinical signs were observed during the observation period in all 200 mg/kg treated animals. Hunched posture and somnolence were observed on test day 1 in all females treated at 2000 mg/kg and persisted in one female animal on test day 2.
- Gross pathology:
- Grey weight distended stomach with gas was observed at the necropsy of all female animals treated at 2000 mg/kg. No macroscopic findings were observed at the necropsy of the 200 mg/kg animals.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on these observations and according to the Annex 3b of the OECD 423, the median lethal dose for the acute oral toxicity of CA 2814 B (Intermediate of CGA 276854) in rats of both sexes observed for a period of 14 days is estimated to be:
LD50 (male rat): >200 mg/kg body weight.
LD50 (female rat): >200 mg/kg body weight, <2000 mg/kg body weight - Executive summary:
Groups of HanIbm: WIST (SPF) rats were treated with CA 2814 B (Intermediate of CGA 276854) at 200 mg/kg (3 males/females) or 2000 mg/kg (3 females) by oral gavage. The test item was diluted in vehicle (polyethylene glycol, PEG 300) at a concentration of 0.02 or 0.2 g/ml and administered at a volume of 10 ml/kg. The animals were examined for clinical signs four times during test day 1 and once daily during test days 2 – 15. Mortality/viability was recorded together with clinical signs at the same time intervals on test day 1 and then twice daily on test days 2 – 15. Body weights were recorded on day 1 prior to administration and on days 8 and 15. All animals were necropsied and examined macroscopically.
All male and female animals treated at 200 mg/kg survived until scheduled necropsy. All female animals treated at 2000 mg/kg were found dead, on test day 2 (2 animals), 1 on test day 3 (1 animal).
No clinical signs were observed during the observation period in all 200 mg/kg treated animals. Hunched posture and somnolence were observed on test day 1 in all females treated at 2000 mg/kg and persisted in one female animal on test day 2.
The body weight of the animals was within the range commonly recorded for animals of this strain and age.
Grey weight distended stomach with gas was observed at the necropsy of all female animals treated at 2000 mg/kg. No macroscopic findings were observed at the necropsy of the 200 mg/kg animals.
Based on these observations and according to the Annex 3b of the OECD 423, the median lethal dose for the acute oral toxicity of CA 2814 B (Intermediate of CGA 276854) in rats of both sexes observed for a period of 14 days is estimated to be:
LD50(male rat): >200 mg/kg body weight.
LD50 (female rat): >200 mg/kg body weight, <2000 mg/kg body weight
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