Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-849-4 | CAS number: 100-41-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A study of the skin absorption of ethylbenzene in man.
- Author:
- Dutkiewicz T & Tyras H
- Year:
- 1 967
- Bibliographic source:
- Br J Ind Med, 24: 330-332.
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: human epidemiology data
- Principles of method if other than guideline:
- Test method: Human data; Study of the absorption of ethylbenzene through the skin of the hand and the forearm in men.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- 0.2 ml of ethylbenzene (173.9 mg)
Constituent 1
Test animals
- Species:
- human
- Details on test animals or test system and environmental conditions:
- Test subjects: 7 men volunteers.
Administration / exposure
- Route of administration:
- other: dermal contact
- Details on exposure:
- 0.2 ml of ethylbenzene (173.9 mg) was introduced with a syringe into a watch glass (4.7 cm in diameter) which was tightly fixed to the skin of the forearm. The exposed skin area was 17.3 cm2.
- Duration and frequency of treatment / exposure:
- 10 -15 minutes
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2 ml of ethylbenzene (173.9 mg)
Results and discussion
Any other information on results incl. tables
Study observed:
Ethylbenzene was absorbed rapidly via the human skin.
The rate of absorption of ethylbenzene ranged from 22 to 33 mg/cm2/hr.Applicant's summary and conclusion
- Conclusions:
- Ethylbenzene showed rapid absorption via the human skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
