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EC number: 420-380-5
CAS number: 136465-81-1
The 24, 48, 72 and 96 hour median lethal concentrations (LC50) of
PTH-Decahydroamide to the freshwater fish, rainbow trout (Oncorhynchus
mykiss previously known as Salmo gairdneri) were determined under static
test conditions at a temperature of 15 ± 1 °C. The 96 hour LC50 = 68 mg
PTH-Decahydroamide/litre with 95% confidence intervals of 57 to 84 mg/L. The
highest test concentration causing no mortality within the period of the
test was 32 mg/L. The lowest that caused 100% mortality within the
period of the test was 100 mg/L.
The 24 and 48 hour EC50 values of PTH-Decahydroamid to Daphnia magna
were determined under static test conditions at a temperature of 20 ± 1
°C. The 48 hour EC50 was 45 mg PTH-Decahydroamid/litre with 95%
confidence intervals of 33 to 65 mg/L. The highest nominal test
concentration causing no immobility was 5.6 mg/L and the lowest that
caused 100% immobility was 180 mg/L.
The toxicity of the test substance to aquatic algae was determined using
OECD method 201. It was determined that PTH-Decahydroamide (Ro
31-9373/000) inhibited cell growth and reduced growth rate of Scenedesmus
subspicatus significantly under the conditions of the present study
at nominally 10 mg/l and higher. The inhibition rates were estimated for
both the algal biomass b and the growth rate R after 72 hours test
duration; based on nominal concentrations.
EbC50 (0-72 h) 46 mg/l
ERC50 (0-72 h) 74 mg/l
The NOEC was 4.8 mg/l for both cell growth inhibition and growth rate
reduction when based on nominal concentrations. Since this concentration
was below the detection limit of PTH-decahydroamide (Ro 31-9373/000) in
water samples, no actual concentration could be determined.
No significant inhibition in respiration rate of the sludge (> 10 %) was
recorded at 100 mg PTH-decahydroamide (Ro 31-9373/000) per litre. Thus
under the conditions of the test PTH-decahydroamide (Ro 31-9373/ 000)
was not toxic to waste water bacteria.
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