Registration Dossier
Registration Dossier
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EC number: 273-761-1 | CAS number: 69012-64-2 Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific review by authorative international body.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS initial assessment report for SIAM 19. Synthetic amorphous silica and silicates.
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications, Berlin.
Materials and methods
- Principles of method if other than guideline:
- OECD evaluated the available test data on synthetic amorphous silica.
- GLP compliance:
- no
- Remarks:
- Review - both yes and no
Test material
- Reference substance name:
- 112945-52-5; 112926-00-8
- IUPAC Name:
- 112945-52-5; 112926-00-8
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Tradenames: Aerosil 200; Sipernat 22S; Sident 9; ULTRASIL VN 3; Syloid 244; Zeofree 80; Tixosil 63; Tixosil 375
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Time point:
- other: 24 hours
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: hydrophilic precipitated silica; slight erythemas in 4/6 animals
- Irritant / corrosive response data:
- The studies with synthetic amorphous shoved that silica were not irritating to the skin of a rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- OECD (2004) includes eight skin irritation studies, of which three were regarded as critical studies for SIDS endpoint. These three studies were conducted with hydrophilic pyrogenic or precipitated silica. None of the studies showed skin irritating effects.
- Executive summary:
In OECD (2004), hydrophilic pyrogenic or precipitated silica were tested by exposing rabbits to 0.19 g or 0.5 g of dry or moistened test item under occlusive conditions for 4 or 24 hours. These synthetic amorphous silica were not irritating to skin under experimental conditions. However, these compounds may produce skin dryness following prolonged and repeated exposure.
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