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Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished study report cited in a peer-reviewed publication
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see below
- GLP compliance:
- no
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: ca. 140 g
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- clean air
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- not further specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 hrs
- Frequency of treatment:
- five 7 hour periods per week over 4 weeks
- Remarks:
- Doses / Concentrations:
18995 mg/m3
Basis:
nominal conc. - No. of animals per sex per dose:
- 10 m / 10 f
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- not further specified
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: yes (daily)
DETAILED CLINICAL OBSERVATIONS: yes (daily)
BODY WEIGHT: yes (weekly)
FOOD CONSUMPTION: no data
FOOD EFFICIENCY: no data
WATER CONSUMPTION: no data
OPHTHALMOSCOPIC EXAMINATION: no data
HAEMATOLOGY: yes (at termination)
CLINICAL CHEMISTRY: yes (at termination)
URINALYSIS: no data
NEUROBEHAVIOURAL EXAMINATION: no data - Sacrifice and pathology:
- internal organs were weighed and examined macroscopically
- Statistics:
- no data
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Dose descriptor:
- NOAEC
- Effect level:
- 18 995 mg/m³ air
- Sex:
- male/female
- Critical effects observed:
- not specified
- Conclusions:
- In a vapour inhalation study, groups of 10 male and 10 female rats were exposed to a concentration of 0 or 18995 mg/m3 on 7 hours/day on 5 days/week over 4 weeks. The treatment gave no indications for adverse effects concerning clinical symptoms or behaviour, body weight gain, blood composition or clinical-chemical parameters. At necropsy, the microscopic examination of internal organs showed no adverse effects and also organ weights were unchanged.
- Executive summary:
- In a vapour inhalation study, groups of 10 male and 10 female rats were exposed to a concentration of 0 or 18995 mg/m3 on 7 hours/day on 5 days/week over 4 weeks. The treatment gave no indications for adverse effects concerning clinical symptoms or behaviour, body weight gain, blood composition or clinical-chemical parameters. At necropsy, the microscopic examination of internal organs showed no adverse effects and also organ weights were unchanged.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 18 995 mg/m³
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - local effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished study report cited in a peer-reviewed publication
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see below
- GLP compliance:
- no
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: ca. 140 g
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- clean air
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- not further specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 hrs
- Frequency of treatment:
- five 7 hour periods per week over 4 weeks
- Remarks:
- Doses / Concentrations:
18995 mg/m3
Basis:
nominal conc. - No. of animals per sex per dose:
- 10 m / 10 f
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- not further specified
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: yes (daily)
DETAILED CLINICAL OBSERVATIONS: yes (daily)
BODY WEIGHT: yes (weekly)
FOOD CONSUMPTION: no data
FOOD EFFICIENCY: no data
WATER CONSUMPTION: no data
OPHTHALMOSCOPIC EXAMINATION: no data
HAEMATOLOGY: yes (at termination)
CLINICAL CHEMISTRY: yes (at termination)
URINALYSIS: no data
NEUROBEHAVIOURAL EXAMINATION: no data - Sacrifice and pathology:
- internal organs were weighed and examined macroscopically
- Statistics:
- no data
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Dose descriptor:
- NOAEC
- Effect level:
- 18 995 mg/m³ air
- Sex:
- male/female
- Critical effects observed:
- not specified
- Conclusions:
- In a vapour inhalation study, groups of 10 male and 10 female rats were exposed to a concentration of 0 or 18995 mg/m3 on 7 hours/day on 5 days/week over 4 weeks. The treatment gave no indications for adverse effects concerning clinical symptoms or behaviour, body weight gain, blood composition or clinical-chemical parameters. At necropsy, the microscopic examination of internal organs showed no adverse effects and also organ weights were unchanged.
- Executive summary:
- In a vapour inhalation study, groups of 10 male and 10 female rats were exposed to a concentration of 0 or 18995 mg/m3 on 7 hours/day on 5 days/week over 4 weeks. The treatment gave no indications for adverse effects concerning clinical symptoms or behaviour, body weight gain, blood composition or clinical-chemical parameters. At necropsy, the microscopic examination of internal organs showed no adverse effects and also organ weights were unchanged.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 18 995 mg/m³
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a vapour inhalation study, groups of 10 male and 10 female rats were exposed to a concentration of 0 or 18995 mg/m3 on 7 hours/day on 5 days/week over 4 weeks. The treatment gave no indications for adverse effects concerning clinical symptoms or behaviour, body weight gain, blood composition or clinical-chemical parameters. At necropsy, the microscopic examination of internal organs showed no adverse effects and also organ weights were unchanged.
No testing of repeated oral toxicity is required since valid data on long-term (carcinogenicity) oral toxicity are available.
No testing of repeated dermal toxicity is required since valid data on long-term (carcinogenicity) oral toxicity are available.
Justification for classification or non-classification
Due to the effect levels obtained in the subacute inhalation toxicity studies, no classification according to EU and GHS criteria is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.