Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-697-3 | CAS number: 1003-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no GLP study No OECD and EU guidelines were followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Method: a) Range finder: Initially, groups of two rats were given a single oral dose of the undiluted test material by gavage using an all metal stomach tube.
b) Animals were each given a single oral dose of the test material at the specified level. animals were observed at 1/4, 1 and 4 hours after treatment and then once daily for fourteen days and the mortalities recorded. Evidence of overt toxicity was also noted. - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentylamine
- EC Number:
- 213-697-3
- EC Name:
- Cyclopentylamine
- Cas Number:
- 1003-03-8
- Molecular formula:
- C5H11N
- IUPAC Name:
- cyclopentanamine
- Reference substance name:
- cyclopenylamine
- IUPAC Name:
- cyclopenylamine
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A . Tuck and Sons Limited, Battlesbridge, Essex
- Weight at study initiation: 150 - 300 g
- Fasting period before study: yes, overnight
- Housing: Animals were housed by sex in suspended metal cages with mesh floors. A maximum number of five rats were housed in each cage.
- Diet: ad libitum, Rat Diet, supplied by Nottingham University, School of Agriculture, Sutton Bonington, Nr . Louqhborough, Leics .
- Water: water (mains tap), ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 + 3°C
- Air changes (per hr): a minimum of 20 air changes per hour
- Photoperiod (hrs dark / hrs light): the lighting cycle was 14 hours on, 10 hours off
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: a) range finder: 0.05, 0.125, 0.25 mL/kg; b) main test: 0.058, 0.05, 0.085, 0.146, 0.25 mL/kg
- Amount of vehicle: 400 mg/mL - Doses:
- a) range finder: 20, 50, 100 mg/kg bw
b) main test: 11.69, 20, 34.2, 58.5, 100 mg/kg bw - No. of animals per sex per dose:
- a) range finder: 1
b) main test: 5 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (main test)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 26.15 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 20.41 - 33.51
- Clinical signs:
- No overt signs of toxicity were oberseved in any of the animals dosed at 11.69 mg/kg bw. At the 20.0 mg/kg bw and 34.2 mg/kg bw dose levels symtoms consisted of subdued activity, pilar erection and anorexia. Survivors at both dose levels showed a marked reduction in bodyweight gain throughout the fourteen day observation period, and two rats at 34.2 mg/kg bw showed pilar erection to days 12 and 14 respectively.
Symptoms at the 58.5 mg/kg bw level consisted of subdued an activity, pilar erection and collapse prior to death. Similar effects were observed in the 100 mg/kg bw group with animals also showing body tremors 4 hours after dosing. - Gross pathology:
- Survivors at 20.0 mg/kg bw and 34.2 mg/kg bw showed evidence of anorexia, that is significantly reduced bodyweight gain. Gross necropsy of survivors (one male and one female from each group)revaled no abnormal macroscopic lesions.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.