Registration Dossier
Registration Dossier
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EC number: 212-556-3 | CAS number: 826-55-1
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study results are considered because the substance is in the Applicability Domain (AD) of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- Developmental Toxicity model (CAESAR) (version 2.1.4)
- Author:
- Laboratory of Environmental Chemistry and Toxicology of Mario Negri Institute of Pharmacological Research.
- Bibliographic source:
- VegaNIC v.1.0.6
- Report date:
- 2013
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R6, May 2008
- Principles of method if other than guideline:
- General model for estimating the developmental toxicity.
Test material
- Reference substance name:
- 2-phenylisobutyric acid
- EC Number:
- 212-556-3
- EC Name:
- 2-phenylisobutyric acid
- Cas Number:
- 826-55-1
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 2-methyl-2-phenylpropanoic acid
- Details on test material:
- SMILE: CC(C)(C1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C10H12O2/c1-10(2,9(11)12)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,11,12)
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study results are in the Applicability Domain (AD) of the models. Therefore, the substance is development toxicant.
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