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EC number: 266-164-2 | CAS number: 66108-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.10.1984
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize scoring procedure-Acute Toxicology Guidelines, Acute skin and Eye Irritation Tests
- Principles of method if other than guideline:
- Draize scoring procedure-Acute Toxicology Guidelines, Acute skin and Eye Irritation Tests was used. Skin irritancy potential was assessed by applying 0.25 gram Iohexol to intact and abraded skin of New Zealand White rabbits. Less than the standard 0.5 gram of compund was used because of the bulkiness of the compound. Using the Draize scoring procedure, reactions were evaluated at 24 and 72 hours to obtain the primary irritation index. Following application to six areas (three intact and three abraded).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iohexol
- EC Number:
- 266-164-2
- EC Name:
- Iohexol
- Cas Number:
- 66108-95-0
- Molecular formula:
- C19H26I3N3O9
- IUPAC Name:
- 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Preparation of test site:
- abraded
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: Primary Irritation Index
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: animal:. Time point: 24 hr. (migrated information)
- Irritation / corrosion parameter:
- other: other: Primary Irritation Index
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: animal:. Time point: 72 h. (migrated information)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: other: Draize scoring procedure
- Conclusions:
- The results indicated that Iohexol was not irritating (Primary Irritation Index=0)
- Executive summary:
Skin irritation potential was assessed by applying 0.25 gram Iohexol to intact and abraded skin of New Zealand White rabbits. Less than the standard 0.5 gram of compund was used because of the bulkiness of the compound. Using the Draize scoring procedure, reactions were evaluated at 24 and 72 hours to obtain the primary irritation index. Following application to six areas (three intact and three abraded), the results indicated that Iohexol was non-irritating (Primary Irritation Index=0)
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