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EC number: 485-110-0 | CAS number: 53535-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2012-03-29 to 2012-04-02
- Reliability:
- 2 (reliable with restrictions)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 485-110-0
- EC Name:
- -
- Cas Number:
- 53535-81-2
- Molecular formula:
- Hill formula: C5H11LiO CAS formula: C5H12O.Li
- IUPAC Name:
- lithium(1+) 2-methylbutan-2-olate
- Reference substance name:
- Lithium 2-methylbutan-2-olate
- IUPAC Name:
- Lithium 2-methylbutan-2-olate
Constituent 1
Constituent 2
Test animals
- Species:
- other: n.a.
- Strain:
- other: n.a.
- Details on test animals or test system and environmental conditions:
- Not indicated; in vitro test
Test system
- Type of coverage:
- other: n.a.
- Preparation of test site:
- other: n.a.
- Vehicle:
- other: n.a.
- Controls:
- no
- Amount / concentration applied:
- not indicated
- Duration of treatment / exposure:
- not indicated
- Observation period:
- not indicated
- Number of animals:
- not indicated
- Details on study design:
- The international Corrositex assay kit is an In vitro method for determining the corrosive potential of chemical substances. The results of this assay were used to determine the United Nations Transport Regulations Packaging Group. For detailed test procedure see Sect. "Any other information on materials and methods incl. tables"
Results and discussion
In vivo
- Irritant / corrosive response data:
- The results of the categorization screen indicated that the test article, Lithium t-Amoxide, fell into category 1. For further Information, see Sect. "Remarks on results incl. tables and figures"
- Other effects:
- none
Any other information on results incl. tables
One run has been performed:
Sample Nr. |
1 |
2 |
3 |
4 |
Detection Time hr:min:sec |
00:26:05 |
00:26:05 |
00:26:05 |
00:26:05 |
Start Time |
00:00:00 |
00:01:36 |
00:03:12 |
00.04:46 |
CORROSITEX Time |
00:26:05 |
00:24:29 |
00:22:53 |
00:21:19 |
Convert to Minutes |
26.08 |
24.48 |
22.88 |
21.32 |
Mean of 4 Replicates |
23.69 |
According to the results of the Corrositex TM Assay, the test article, Lithium t-Amoxide, has to be classified as corrosive and allocated to packing group II according to the UN Dangerous Goods Transport Regulations
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: UN Dangerous Goods Transport Regulations
- Conclusions:
- Lithium t-Amoxide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium t-Amoxide was found to be corrosive and assigned to packing group II. Lithium t-Amoxide has to be classified as corrosive Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC.
- Executive summary:
Studies to determine the animal toxicity cannot be performed with Lithium t-Amoxide because of its reactivity and corrosive properties. Lithium t-Amoxide is pyrophoric and would react violently on exposure to animal tissues, Instead, Lithium t-Amoxide was tested for skin irritation/corrosion. Lithium t-Amoxide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium t-Amoxide was found to be corrosive and assigned to packing group II.
Based on this data the substance is also found to be:
- corrosive: Cat. 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and
- corrosive (R34) according to Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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