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EC number: 611-084-9 | CAS number: 54041-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
- Details on sampling:
- at the beginning and at the end of testing
- Vehicle:
- no
- Remarks:
- Use of ultrasonic bath
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Name: Daphnia magna STRAUS, parthenogenetic females
- Source: Strain of Bundesgesundheitsamt Berlin
- Age: 6 - 24 h
- Maintenance and Acclimatisation: A population of parthenogenetic females of synchronized age structure has been maintained in the test facility under constant temperature conditions (20 +/- 1 °C) at a 16 : 8 hour light-dark photoperiod (illumination: < 1000 lux). The culture water (so-called 'M4 medium') was partly renewed once a week. The Daphnia were exclusively fed with unicellular green algae (Desmodesmus subspicatus) 'ad libitum'. Mortalities of parent Daphnia during the culture period were recorded daily in a semi-quantitative way. The neonates were separated from their parent Daphnia by filtration prior to the acute test.
- Culture and dilution water: Reconstituted water (so-called 'M4 medium') was used for the maintenance of the test animals and the preparation of stock and test solutions of the test item. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 14.8 °dH
- Test temperature:
- 21.0 - 21.2 °C
- pH:
- 8.1
- Dissolved oxygen:
- 9.2 - 9.3 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L
measured: 112 and 115 mg/L - Details on test conditions:
- - Test vessels: glass beakers covered with watch glasses
- Experimental design: 1 test concentration plus 1 control, 10 neonates per vessel, 2 replicates per concentration/control
- no feeding during the exposure period
- static system
- Method of initiation: neonates were placed in prepared media
- Photoperiod: 16 h light : 12 h dark
- Aeration: none
- Test item concentration/s: 100 mg/L
- Method of administration: stock solution
- Medium renewal: none
- Duration of exposure: 48 hours
- Criteria of effects: The criterion of adverse effects used in this study was the item-induced the loss of locomotory actions of the neonates, observed after 24 and 48 hours. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 114 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- In the control <= 10 % of the daphnids should have been immobilised; dissolved oxygen concentration at the end of the test >= 3 mg/L in control and test vessels
- Conclusions:
- No toxic effects against daphnids were observed at a limit test concentration of 100 mg/L for the test substance after 48 h.
- Executive summary:
A study was performed to assess the acute toxicity of the test substance to daphnids under static conditions as described in the Council Regulation (EC) No 92/69, Method C.2 'Acute toxicity for Daphnia' (1992)..
The daphnids were exposed to a limit test concentration of nominally 100 mg/L of the test substance dissolved in water (10 neonates/vessel, 2 replicates/concentration).
Observations were made on the swimming ability and the immobilisation rate, respectively, after 24 and 48 hours of exposure. The following value was determined EC0 >= 114 mg/L (arithmetic mean of measured concentration).
No toxic effects against daphnids were observed at a limit test concentration of 100 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March-August 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 14669 (1999) Water Quality - Determination of acute lethal toxicity to marine copepods (Copepoda; Crustacea)
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 5667-16 (1998) Water Quality Sampling – Guidance on biotesting of samples
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all test concentrations and control sampled
- Sample storage conditions before analysis: below 5 °C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: FOE-hydroxy was characterised as poorly soluble and test solutions were therefore prepared by Water Accommodated Fractions (WAFs).
- Evidence of undissolved material (e.g. precipitate, surface film, etc): Floating particles - Test organisms (species):
- other aquatic crustacea: Acartia tonsa
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 +- 2°C
- pH:
- 8.12-8.14
- Dissolved oxygen:
- 89-98 %
- Salinity:
- 36 ‰
- Nominal and measured concentrations:
- Range finding test: Nominal noncentration (mg/L) 1, 10, 100 and 1000, Analytical concentrations (mg/L) 1, 9, 98, 980
Definitive test: Nominal concentrations (mg/L) 10, 32, 100, 320 and 1000 , Analytical concentrations (mg/L) 9, 30, 90, 310, 950 - Details on test conditions:
- TEST SYSTEM
- Test vessel: Tests were conducted in 100 ml capacity borosilicate glass crystallising dishes, each containing 50 mL of test medium covered with soda glass watch covers.
- Aeration: yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Natural seawater was supplied by pump from Scapa Flow, Orkney and was UV sterilised and filtered to 0.2 μm. The salinity of the seawater was 36 ±4 ‰.
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 1, 10, 100 and 1000 mg/L (Nominal)
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 85 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 492 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Mortality: yes
- LC50: 1.05 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- FOE-hydroxy exhibited a 48h LC50 value of 85 mg/L (Water Accommodated Fractions (WAFs)) to the marine copepod Acartia tonsa in the aqueous phase.
- Executive summary:
FOE-hydroxy exhibited a 48h LC50 value of 85 mg/L (Water Accommodated Fractions (WAFs)) to the marine copepod Acartia tonsa in the aqueous phase.
Referenceopen allclose all
Description of key information
A study was performed to assess the acute toxicity of the test substance to daphnids under static conditions as described in the Council Regulation (EC) No 92/69, Method C.2 'Acute toxicity for Daphnia'(1992)..
The daphnids were exposed to a limit test concentration of nominally 100 mg/L of the test substance dissolved in water (10 neonates/vessel, 2 replicates/concentration).
Observations were made on the swimming ability and the
immobilisation rate, respectively, after 24 and 48 hours of exposure.
The following value was determined EC0 >= 114 mg/L (arithmetic mean of
measured concentration).
No toxic effects against daphnids were observed at a limit test concentration of 100 mg/L.
FOE-hydroxy exhibited a 48h LC50 value of 85 mg/L (Water Accommodated Fractions (WAFs)) to the marine copepod Acartia tonsa in the aqueous phase.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 114 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 85 mg/L
Additional information
EC50 for freshwater invertebrates should read "> 114 mg/L".
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