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Diss Factsheets
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EC number: 939-180-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case reports
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short communication. Case reports and patch testing.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from aziridine crosslinker
- Author:
- Ibbotson SH and Lawrence CM
- Year:
- 1 994
- Bibliographic source:
- Contact Dermatitis; 30: 306
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Patch testing
Test material
- Reference substance name:
- 2-ethyl-2-[[3-(2-methylaziridin-1-yl)propionyl]methyl]propane-1,3-diyl bis(2-methylaziridine-1-propionate)
- EC Number:
- 264-763-3
- EC Name:
- 2-ethyl-2-[[3-(2-methylaziridin-1-yl)propionyl]methyl]propane-1,3-diyl bis(2-methylaziridine-1-propionate)
- Cas Number:
- 64265-57-2
- Molecular formula:
- C24H41N3O6
- IUPAC Name:
- 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate (non-preferred name)
Constituent 1
Method
- Type of population:
- occupational
- Clinical history:
- Case number 1:
A 43-year-old man presented with a 6-month history of a rash on his face, arms and body. He had worked as a water-based printer for 27 years, but commenced work at his current employment 7 months prior to the onset of skin problems. He first noticed a rash on his fingers and wrists, initially partially responsive to topical corticosteroids, but subsequently spreading to his legs, arms and trunk over a 2-month period. The rash improved whilst off work, but recurred within 2 days of return. He had no history of atopy or skin disorder and was receiving no medication. Examination revealed a severe, acute, vesicular eczema of the dorsum and palms of the hands, fingers, head and neck. There was no sparing of light-protected areas and eczema was evident on the flank, thighs adjacent to the pockets and left great toe.
Case number 2:
A 57-year-old man presented with a 5-month history of a rash on his face, limbs and body. He had worked as a printer all his adult life and joined his present employment 5 months prior to the onset of the rash. Skin involvement was first noticed on the dorsum of the
fingers and on the wrists. This improved whilst he was on holiday and during periods away from work and recurred on return, worsening and spreading to the head, neck and trunk. He was otherwise well, without any history of atopy or skin disorder and receiving no medication. On examination, eczema of the upper and lower arms, hands, fingers, trunk, head and neck was evident.
Light-protected areas were not spared and the sides of the thighs were involved, although the skin under the underpants was spared. - Route of administration:
- dermal
- Details on study design:
- Patch testing
In each case, patch tests were performed to the Europe standard series, a face and an industrial series. Case number 1 reacted to thiuram mix (1.0% pet.) and had worn rubber gloves in the factory. Patch tests were also performed to ingredients of the water-based inks, including dimethylaminoethanol (0.01, 0.1, 1.0% aq.) and crosslinker (0.1% aq.). Both men gave positive reactions to crosslinker at 3 days, on both back and upper arm sites.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Patch tests were performed to the Europe standard series, a face and an industrial series. Case number 1 reacted to thiuram mix (1.0% pet.) and had worn rubber gloves in the factory. Patch tests were also performed to ingredients of the water-based inks, including dimethylaminoethanol (0.01, 0.1, 1.0% aq.) and crosslinker (0.1% aq.). Both men gave positive reactions to crosslinker at 3 days, on both back and upper arm sites.
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