Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-266-6 | CAS number: 1179883-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure according to national standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1999
Materials and methods
- Type of study / information:
- A single application closed patch epicutaneous test under occlusion was performed in 20 male and female, healthy volunteers for a period of 24 h to determine the skin irritating potential of the test substance for the evaluation of skin compatibility.
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines for the Assessment of Skin Tolerance of Potentially Irritant Cosmetic Ingredients (COLIPA, 1997)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- according to GCP
Test material
- Reference substance name:
- not applicable, UVCB substance
- Molecular formula:
- not applicable, UVCB substance
- IUPAC Name:
- not applicable, UVCB substance
- Reference substance name:
- 928-176-2
- EC Number:
- 928-176-2
- IUPAC Name:
- 928-176-2
- Details on test material:
- - Name of test material (as cited in study report): trade name given
- Physical state: white solid
- Analytical purity: 20% AS in cosmetic alcohol
- Composition of test material, percentage of components: 30% C16/C18-APG, 70% C16/C18 fatty alcohols
Constituent 1
Constituent 2
Method
- Ethical approval:
- not specified
- Details on study design:
- The test substance (70 µL) at 20% AS (active substance content) was each applied to an occlusive patch (Finn Chamber on Scanpor, 12 mm diameter) and placed on the back of the volunteers. After 24 h exposure, patches were removed and skin irritation was monitored for 6, 24, 48 and 72 h. Different reference substances (1% AS Texapon N25, 0.5% AS sodium dodecyl sulphate (SDS), demineralised water, physiological saline and cosmetic alcohol) were tested in parallel. The skin compatibility was assessed by comparison to the reference substances SDS and Texapon N25.
- Details on exposure:
- TYPE OF EXPOSURE: epicutaneous, occlusive
TYPE OF EXPOSURE MEASUREMENT: based on calculation
EXPOSURE LEVELS: 20% AS in cosmetic alcohol
EXPOSURE PERIOD: 24 h
POSTEXPOSURE PERIOD: 6, 24, 48 and 72 h
DESCRIPTION OF EXPOSURE GROUPS:
- Number of subjects exposed: 20 healthy volunteers
- Sex: male and female
- Age: not restricted
Results and discussion
- Results:
- After exposure to the test substance (20% AS), 2 moderate erythema and slight scaling were observed. The mean scores after 6, 24, 48 and 72 h were 0.2 for erythema and 0.45 for erythema, oedema, scaling and fissure. The skin compatibility of the test substance compared to 1% AS Texapon N25 and 0.5% AS SDS was good.
Applicant's summary and conclusion
- Conclusions:
- After 24 h exposure period, the test substance at 20% AS in cosmetic alcohol was not irritating to human skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.