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Diss Factsheets
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EC number: 941-224-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not performed under GLP compliance, however, the study was conducted according to standards of that time, therefore the study is considered to be adequate, reliable and relevant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no scoring, observation period 7 days
- GLP compliance:
- no
Test material
- Reference substance name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- EC Number:
- 941-224-7
- Molecular formula:
- C14H25O7S.Na
- IUPAC Name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- Test material form:
- other: waxy solid
- Details on test material:
- - Name of test material (as cited in study report): Aerosol AY
- Physical state: White, waxy solid
- Analytical purity: >97%
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Isomers composition: Not provided
- Purity test date: Not provided
- Lot/batch No.: SPS 900A-MH and additional samples without No
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
- Storage condition of test material: Not provided
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- Not provided
Test system
- Controls:
- no
- Amount / concentration applied:
- 10 mg
- Duration of treatment / exposure:
- 30 seconds (eyelids held close)
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 5 male albino rabbits
- Details on study design:
- A quantity of approximately 10 mg of the product was placed in the conjunctival sac of the left eye of each of 5 male albino rabbits. The lids were held close for about 30 seconds after introduction of the dose, and the eye was examined immediately thereafter, and again over the next several days.
Results and discussion
In vivo
Results
- Remarks on result:
- other: No scores available
- Irritant / corrosive response data:
- There was an immediate reaction of pain or discomfort to application of the dose, but no more serious sign of immediate injury than a somewhat excessive amount of lacrimation. By 24 hours after the dose a moderate degree of conjunctivitis had developed. This subsided gradually over the succeeding 24 to 48 hours and was associated with a certain amount of discharge from the eye. By the fourth day following that of the dose, most eyes had regained their normal appearance, and continued in good condition for the remainder of a seven-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Introduction of small quantities of the test item containing >97% active ingredient into the rabbit eye resulted in a moderate to severe conjunctivitis of several days duration, but no further injury.
- Executive summary:
A quantity of approximately 10 mg of the test item containing > 97% active ingredient was placed in the conjunctival sac of the left eye of each of 5 male albino rabbits. The lids were held close for about 30 seconds after introduction of the dose, and the eye was examined immediately thereafter, and again over the next several days.There was an immediate reaction of pain or discomfort to application of the dose, but no more serious sign of immediate injury than a somewhat excessive amount of lacrimation. By 24 hours after the dose a moderate degree of conjunctivitis had developed. This subsided gradually over the succeeding 24 to 48 hours and was associated with a certain amount of discharge from the eye. By the fourth day following that of the dose, most eyes had regained their normal appearance, and continued in good condition for the remainder of a seven-day observation period.
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