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EC number: 249-220-0 | CAS number: 28783-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 26 february 1996 to 9 august 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A well documented GLP study according to european guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
- IUPAC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
- Reference substance name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride
- EC Number:
- 249-220-0
- EC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride
- Cas Number:
- 28783-41-7
- Molecular formula:
- C7H9NS.ClH
- IUPAC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in the study report): chlorhydrate de 4, 5, 6, 7-tétrahydrothiéno [3, 2-c] pyridine de code PCR 0665
- Substance type: organic
- Physical state: white powder
- Analytical purity: 99.4%
- Lot/batch No.: 4 SNS 011
- Solubility: soluble in water
- Stability: stable under normal conditions of use
- Decomposition: around 244°C
- Storage condition of test material: store the container closed and in well ventilated area
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Details on test solutions:
- As the test substance hydrochloride, 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine code PCR 0665 is soluble in water, a stock solution of 1 g/l is prepared by dissolving the analyte in the test medium. After stirring for 2 hours at 20 °C, the solution was filtered to 0.22 µm to remove any suspended particles. This stock solution is then diluted in the test medium to obtain the appropriate test concentrations.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Daphnies: Daphnia magna Straus 1820 (Cladocera crustacea)
- Source: INERIS laboratory
- Method of breeding: continuous and balanced breeding in accordance with Appendix A of the standard AFNOR NF T 90 301.
- Feeding: TetraMin + algae
- Illumination: daylight + artificial light with a photoperiod of 16 hours light and 8 hours of darkness.
Study design
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- in darkness
Test conditions
- Test temperature:
- 20°C +/- 2°C
- pH:
- Filtered stock solution: 7.24
Test solution at the highest tested concentration: 7.30 - Dissolved oxygen:
- Dissolved oxygen content measured at the end of the end of the test (after 48h) is higher than 2 mg/l for the test substance.
- Nominal and measured concentrations:
- Measured concentrations: 36 - 51 - 72 - 100 - 145 - 197 - 288 and 394 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass tubes for single use
- Fill volume: sufficient capacity for 10 ml
- Aeration: none
- No. of organisms per vessel: 5 daphnies per vessel (2 ml for each daphnie)
- No. of vessels per concentration (replicates): 4 vessels for each concentration tested
- No. of vessels per control: 4 vessels each containing 10 ml of test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionized water
- Alkalinity: 0.8 mmol/l
- Ca/mg ratio: 4
TEST CONCENTRATIONS
- Test concentrations: 36 - 51 - 72 - 100 - 145 - 197 - 288 and 394 mg/l - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 141 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 119-169 mg/l
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 72 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 61-83 mg/l
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- < 36 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 288 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- EC50-48h determined by the method of calculation of PROBITS (confidential limits 95%): 141 mg/l (119-169 mg/l).
EC50-24h determined by the method of calculation of PROBITS (confidential limits 95%): 72 mg/l (61-83 mg/l). - Results with reference substance (positive control):
- EC50-24h of potassium dichromate is 1.17 mg/l and is therefore in the range recommended by the AFNOR NF-T-90 301 (0.9-1.5 mg/l).
- Reported statistics and error estimates:
- In the test conditions, the percentage loss of the test substance remained after 48 hours less than 20% for all test concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute toxicity test with daphnia the EC50 of the test substance was found 141 mg/l at 48 h and 72 mg/l at 24h. Thus the substance is not considered toxic to Daphnia magma.
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