Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-047-1 | CAS number: 5619-04-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 June 2014-07 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- thermal analysis
- Remarks:
- (differential scanning calorimetry)
Test material
- Reference substance name:
- Methyl DL-serinate hydrochloride
- EC Number:
- 227-047-1
- EC Name:
- Methyl DL-serinate hydrochloride
- Cas Number:
- 5619-04-5
- Molecular formula:
- C4H9NO3.ClH
- IUPAC Name:
- methyl 2-amino-3-hydroxypropanoate hydrochloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): DL-serine Methylester HCl
- Molecular formula: C4H9NO3.HCl
- Molecular weight: 155.58 g/mol
- Description: White crystalline powder
- Storage condition of test material: At room temperature in the dark
- Expiration date of the lot/batch: 14 September 2014
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- 137 °C
- Decomposition:
- yes
- Decomp. temp.:
- > 150 °C
- Remarks on result:
- other: Melt. pt in K.: 410. Decomp. temp. in K: 423.
Any other information on results incl. tables
PRELIMINARY TEST WITH TGA
From 170°C upwards the weight of the sample decreased significantly. From 178°C upwards there was an abrupt decrease observed which indicates reaction and/or decomposition. After the experiment, a charred molten residue remained in the sample container and partially upon the lid.
DSC EXPERIMENTS
Experiment 1: An endothermic peak between 120°C and 160°C was observed, probably due to melting of the test substance. The extrapolated onset temperature of the peak was 136.97°C. After the experiment, a charred molten residue remained in the sample container. The change of the colour from white to black indicated reaction and/or decomposition.
Experiment 2: To investigate the peak between 120°C and 160°C a repeated heating cycle was applied.
-With the first heating the extrapolated onset temperature was 132.18°C.
-During cooling a small exothermic peak was observed between 120°C and 130°C due to crystallization of the test substance.
-With the second heating an extrapolated onset temperature of 131.75°C was obtained.
-After the experiment, a charred molten residue remained in the sample container.
Experiment 3: To determine if the endothermic effect was indeed due to melting of the test substance, heating was stopped at 150°C and the residue was visually inspected. Extrapolated onset temperature: 135.99°C. After the experiment, a white molten residue remained in the sample container from which it was concluded that the observed endothermic effect was indeed caused by melting of the substance.
Experiment 4: The temperature program was the same as in Experiment 1 and similar results were obtained. Extrapolated onset of the melting peak: 136.69°C. After the experiment, a charred (black) molten residue remained in the sample container.
The melting temperature of the substance was calculated from the values obtained in Experiment 1 (136.97°C) and Experiment 4 (136.69°C).
Applicant's summary and conclusion
- Conclusions:
- In a GLP-compliant study in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200 using differential scanning calorimetry, the melting temperature of the substance has been determined as 137°C. Decomposition of the substance started at 150°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)