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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 695-745-7 | CAS number: 1079221-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Acute oral toxicity:
Only one data is available in a test inspired from OECD guideline 420, where the only dose tested 500 mg/kg bw produced no mortality in rats. However as the tested dose is lower than the one required in a standard limit test (i.e. 2000 mg/kg bw), the result is considered as insufficient for the purpose of classification and labelling.
An additional data summarized in section 7.5.1 (Repeated dose toxicity: oral) gives more information useful for classification. In this 14-day preliminary toxicity test by oral gavage in rats, 5/5 females and 1/5 male dosed at 1000 mg/kg bw were found dead on study day 2, and 4/5 males were sacrificed on study day 4 due to severe clinical signs. This result shows that a dose of 1000 mg/kg bw can be fatal to rats after one or two exposures at this level.
Taking into account these two acceptable data, we can conclude that the test item should be classified as harmful if swallowed (acute toxicity category 4) according to CLP criteria.
Acute dermal toxicity:
Only one data is available in a test inspired from OECD guideline 402, where the only dose tested 500 mg/kg bw produced no mortality in rats. However as the tested dose is lower than the one required in a standard limit test (i.e. 2000 mg/kg bw), the result is considered as insufficient for the purpose of classification and labelling.
However as the test item is poorly absorbed via dermal route (0.106% systematically available in an in-vitro dermal penetration assay, see section 7.1.2), and no toxicity was observed at 500 mg/kg bw by oral and dermal route, no classification for acute dermal toxicity according to CLP criteria is proposed.
Acute inhalation toxicity:
No data is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.