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Diss Factsheets
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EC number: 211-477-1 | CAS number: 647-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although data provided have a report year after 2008, the data was obtained from a journal article which does not provide GLP information.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- 6-2 Fluorotelomer alcohol aerobic biodegradation in soil and mixed bacterial culture
- Author:
- Liu J, Wang N, Szostek B, Buck R, Paniciroli P, Folsom P, Sulecki L and Bellin C
- Year:
- 2 009
- Bibliographic source:
- Chemosphere 78, 437–444
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 302 A (Inherent Biodegradability: Modified SCAS Test)
- Deviations:
- yes
- Remarks:
- Degradation was determined by qualitative analysis of the test substance with LC/MS/MS, study run for 90 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- EC Number:
- 211-477-1
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Cas Number:
- 647-42-7
- Molecular formula:
- C8H5F13O
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Details on test material:
- - Purity: 99%
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, adapted
- Details on inoculum:
- This study used a mixed aerobic bacterial culture developed from activated sludge previously exposed to fluorinated chemicals. However, the bacterial culture was not pre-exposed to any fluorinated chemicals immediately before conducting the biodegradation study.
After the sludge was collected from aeration tanks of an industrial wastewater treatment plant, it was allowed to settle for 5 min and 5 mL of the top phase was transferred to 50 mL of growth medium comprising of a mineral nutrient medium and 0.1% yeast extract. The culture was maintained at 20-25 °C by periodically transferring 0.5 mL of the culture into another 50 mL growth media twice a week. After four consecutive transfers, the culture was spun down to pellets and re-suspended in the mineral nutrient medium as an inoculum and was added to the sample solution to a final OD600 of 0.05 for the degradation study. - Duration of test (contact time):
- 0 - 90 d
Initial test substance concentration
- Initial conc.:
- 2.8 other: µg/mL
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: nutrient medium
- Test temperature: 20–25 °C
- Continuous darkness: yes
- Other: incubated on an orbital shaker at 150 rpm
TEST SYSTEM
- Culturing apparatus: 120-mL glass serum bottles sealed with natural rubber septa
- Number of culture flasks/concentration: Three treatments of duplicate vessels were prepared: (1) untreated (matrix) live culture with 6 µL ethanol; (2) test substance treated live culture; and (3) test substance treated sterile culture. At each sampling time point, a total of six test vessels were sacrificed for sample processing and extraction of tests substance and potential metabolites.
- Measuring equipment: 4900 Micro-GC; The O2 content was also measured at each time point in untreated live culture to approximate O2 content in treated live sample bottles.
- Test performed in closed vessels due to significant volatility of test substance: yes
- Other: The incubation was initiated by aseptically adding 30 mL of the mixed bacterial culture to each test vessel then dosing with 6 µL of test substance stock solution prepared in ethanol.
SAMPLING
- Sampling frequency: 0, 2, 7, 14, 28, 60, and 90 day
- Sampling method: Without breaking the seal, 1.0 mL of the headspace gas was sampled with a gas-tight syringe and analysed for the oxygen content with a 4900 Micro-GC. Then, without breaking the seal, 5 mL of culture was drawn out with a syringe for fluoride measurement. Finally, the entire sample vessel was extracted with 30 mL of acetonitrile injected with a syringe through the septum.
- Sample storage before analysis: frozen, ≈20 °C
Reference substance
- Reference substance:
- not required
Results and discussion
% Degradation
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- (Primary biodegradation)
- Value:
- >= 97.2 - <= 98.4
- Sampling time:
- 7 d
- Remarks on result:
- other: Incomplete mineralisation; Transformation products were identified
- Details on results:
- Test substance biodegradation in mixed bacterial culture was rapid with an estimated half-life of 1.3 days assuming first-order kinetics. The test substance concentration decreased rapidly and stabilised after day 7 at 1.6 - 2.8% of the total mass applied at day 0 (2.8 µg/mL). This would be equal to 97.2 - 98.4% primary degradation by day 7.
Any other information on results incl. tables
Metabolite concentrations reached steady-state after 14 – 28 days.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: Primary biodegradation observed. This study would infer that the test substance would not be regarded as readily or inherently biodegradable.
- Conclusions:
- This study and the conclusions which are drawn from it fulfill the quality criteria (validity, reliability, repeatability).
97.2 - 98.4% primary degradation by day 7 - Executive summary:
Test substance biodegradation was evaluated at 2.8 μg/mL and 20 μg/mL (for metabolite identification) for 90 days in a mixed aerobic bacterial culture developed from activated sludge previously exposed to fluorinated chemicals. Test vessels were 120-mL glass serum bottles sealed with natural rubber septa and the vessels were incubated on an orbital shaker at 150 rpm at 20 – 25 °C. The replicate test and control vessels were extracted and analysed at 0, 2, 7, 14, 28, 60, and 90 days for the test substance and metabolites.
Primary biodegradation in the mixed bacterial culture was rapid with an estimated half-life of 1.3 days assuming first-order kinetics. Test substance concentration decreased rapidly and stabilised after day 7 at 1.6 - 2.8% of the total tests substance mass applied at Day 0. This would be equal to 97.2 - 98.4% primary degradation by day 7. Metabolite concentrations reached steady-state after 14 – 28 days.
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