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Diss Factsheets
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EC number: 700-692-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- July-August 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported study comparable to guideline/standard.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- tested during 3, 30, 60 and 240 min; occlusive exposure rather than semi-occlusive
- GLP compliance:
- yes
- Remarks:
- audited in house
Test material
- Reference substance name:
- Amines, N-(3-aminopropyl)-N-tallow alkyltrimethylenedi-
- EC Number:
- 288-048-0
- EC Name:
- Amines, N-(3-aminopropyl)-N-tallow alkyltrimethylenedi-
- Cas Number:
- 85632-63-9
- IUPAC Name:
- 85632-63-9
- Details on test material:
- Name of test compound: LILAMIN LS 33
(Description Lilamin LS 33: See endpoint 7.2.1. "85632-63-9, Acute toxicity: oral, Kynoch, 1985, RS"
Appearance: brown/yellow liquid
Date of receipt: 4 December 1984
Storage: ambient temperature
Composition:
60-65% tallow alkyl dipropylene triamine
25-30% tallow diamine
5-10% ditallow alkyl propylene diamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Rosemead Rabbits, Rosemead, UK and Morton Commercial Rabbits, Stansted, UK
- Age at study initiation: 9-14 weeks
- Weight at study initiation: 1.9-3.2 kg
- Housing: individually in metal cages with perforated floor
- Diet (e.g. ad libitum): ad lib
- Water (e.g. ad libitum): ad lib
- Acclimation period: yes but no further info
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 19
- Humidity (%): 30-70
- Air changes (per hr): ca. 19
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 31 July To: 9 August 1985
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): test material was warmed prior to dosing and administered as supplied - Duration of treatment / exposure:
- 3, 30, 60 and 240 min in preliminary test
3 min in main study - Observation period:
- 0, 24, 48 and 72 h after patch removal
- Number of animals:
- preliminary test: 2
main study: 3 - Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm square
- % coverage: 10 cm square had been clipped
- Type of wrap if used: impervious Sleek plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after patch removal the tested area was washed with water to remove excess test substance
- Time after start of exposure: after 3, 30, 60 or 240 min of exposure, respectively
SCORING SYSTEM:
EVALUATION OF SKIN REACTIONS
Erythema and eschar formation
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar
formation (injuries in depth) 4
Oedema formation
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well-defined by
definite raising) 2
Moderate oedema (raised approximately 1 mm) 3
Severe oedema (raised more than 1 mm and
extending beyond area of exposure) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis/blanching was observed at 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24/48/72 h
- Score:
- 2.83
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Preliminary test: severe skin reactions with necrosis, chemical burns and blanching were seen following application for 3, 30, 60
min and 4 h.
Main test: necrotic lesions developed in all 3 animals. - Other effects:
- None reported
Any other information on results incl. tables
Summary of dermal lesions following 3-min application (mean of 2 sites per animal)
Animal no. |
Effect |
Hour |
Days after application |
Mean score erythema (24/48/72 h) |
Mean score oedema (24/48/72 h) |
||||
0 |
1 |
2 |
3 |
7 |
14 |
||||
9401 M |
Erythema Oedema |
1 0 |
2 3 |
2 3 |
4A 2 |
- - |
- - |
2.67 |
2.67 |
9411 F |
Erythema Oedema |
1 0 |
2 3 |
2 3 |
4A 2.5 |
- - |
- - |
2.67 |
2.83 |
9461 M |
Erythema Oedema |
1 0 |
2 3 |
2 3 |
4A 3 |
- - |
- - |
2.67 |
3 |
Mean all animals |
2.67 |
2.83 |
A = necrosis/blanching
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Slight erythema was observed immediately upon patch removal after a 3-min exposure; necrosis/blanching was observed 3 days
later. Because a response was noted following up to 3 min exposure and up to 1 h observation, the test compound should be
classified in Category 1A according to OECD-GHS. - Executive summary:
A study was performed to assess the irritancy potential of the test material, LILAMIN LS 33, to the skin of the New Zealand White rabbit. The method used essentially followed OECD Test Guideline 404. Following a preliminary test, a single 3 -min occluded application of the test material to the
intact skin of three rabbits produced slight erythema immediately after patch removal. Necrotic lesions developed in all 3 animals after 3 days.
Because a response was noted following up to 3 min exposure and up to 1 h observation, the test compound should be classified in Category 1A according to OECD-GHS.
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