Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-278-6 | CAS number: 118-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4,6-tribromophenol
- EC Number:
- 204-278-6
- EC Name:
- 2,4,6-tribromophenol
- Cas Number:
- 118-79-6
- Molecular formula:
- C6H3Br3O
- IUPAC Name:
- 2,4,6-tribromophenol
- Test material form:
- solid: granular
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: MANAC, Hiroshima, JAPAN; Lot No.: 70909
- Purity test date: 99.8 wt %
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan Charles River, Atsugi-city, Kanagawa prefecture
- Age at study initiation: 6 weeks
- Weight at study initiation: 5 males of 175 to 202 g body weight and 5 females of 130 to 156 g body weight were selected.
- Fasting period before study: 16 hours
- Housing: 5 rats per cage, breeding cages of 21.5 x 27.5 x 19.5 cm were used; bedding and cage bottom not specified.
- Diet (e.g. ad libitum): ad libitum to food pellets from Oriental Yeast Co, Ltd. No diet details given. Contaminants in food were confirmed within allowable standards.
- Water: tap water ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 2°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): 20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200, 260, 338, 439.4 and 571.2 mg of the test substance (99.8 wt % purity) were suspended in corn oil.
- Amount of vehicle (if gavage): 0.5 mL/100 g bw suspended solution. - Doses:
- 1000, 1300; 1690; 2197 and 2856 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: every 1 hr till 6 hrs after administration. After 6 hrs, twice/day
- Necropsy of survivors performed: yes
- Other examinations performed: Appearances and activities of surviving animals were observed. Dead animals and survived animals were dessected just after died and after 14 days test respectively. Macroscopical and pathological findings were recorded.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 486 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 1 215 - ca. 1 792
- Mortality:
- Deaths of both sexes occurred in the 1300 mg/kg and more groups.
1000 mg/kg - 0%
1300 mg/kg - 40%
1690 mg/kg - 80%
2197 mg/kg - 80%
2866 mg/kg - 100% - Clinical signs:
- other: Hypoactivity was observed in all groups and salivation appeared in most of animals. Furtheremore, in 1300 mg/kg or higher groups of both sexes, chlonic convulsions, tremors, adoption of a prone and/or lateral position were observed before the animals die
- Gross pathology:
- No macroscopic abnormalities were observed by autopsy for either of the dead animals and the survived animals.
Any other information on results incl. tables
Numbers of dead animals by doses
[Males]
------------------------------------------------------------------------------------------
Dose Number of Number of deaths Mortality
(mg/kg) animals day 1 day 2-14
------------------------------------------------------------------------------------------
1000 5 0 0 0 / 5
1300 5 2 0 2 / 5
1690 5 4 0 4 / 5
2197 5 4 0 4 / 5
2856 5 5 - 5 / 5
------------------------------------------------------------------------------------------
[Females]
------------------------------------------------------------------------------------------
Dose Number of Number of deaths Mortality
(mg/kg) animals day 1 day 2 -14
------------------------------------------------------------------------------------------
1000 5 0 0 0 / 5
1300 5 2 0 2 / 5
1690 5 4 0 4 / 5
2197 5 4 0 4 / 5
2856 5 5 - 5 / 5
------------------------------------------------------------------------------------------
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the data obtained, the LD50 of 2,4,6-tribromophenol was determined to be 1486 mg/kg with 95% confidence intervals of 1215 - 1792 mg/kg when administered once orally via gavage to male and female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.