Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: evaluation of available data
Justification for type of information:
Justification for read-across is attached in Section 13 of IUCLID

Data source

Reference
Reference Type:
other: assessment of available data
Title:
Unnamed
Year:
2023

Materials and methods

Principles of method if other than guideline:
evaluation of available data
GLP compliance:
no
Test type:
other: different test types used
Limit test:
no

Test material

Constituent 1
Reference substance name:
SS01-SS07_ZnDBM
IUPAC Name:
SS01-SS07_ZnDBM

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: not classified for acute toxicity as per the CLP Regulation EC No.1272/2008
Conclusions:
LD50 (m/f) > 2000 mg/kg
Executive summary:

As no experimental data is available for the potential acute oral toxicity of Zinc, Bis (1,3-Diphenyl-1,3-propanedionate), the acute oral toxicity data reported in literature of read across substances.


Dtsrting from data available from these read-across substances, it is possible to calculate the LD50 value of the test item.


As the threshold for acute oral toxicity classification according to CLP guideline is 2000 mg/kg bw, a comparison between read-across substances and Zn(DBM)2 solubility has been done.


Differences in water solubility of the different read -across substances is one of the parameters that affects GIT absorption. Low water solubility could be associated to the low acute toxicity of this substance.


As Zn(DBM)2 is not soluble in water, it can be assumed that also this substance does not require acute toxicity classification.