Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 928-282-9 | CAS number: 1174522-28-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation
Not irritating to the skin
Ocular Irritation
Not irritating to eyes
Respiratory Irritation
No studies were located to indicate that Hydrocarbons, C11-C12, n-alkanes, <2% aromatics is a respiratory irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000/4/12-2000/6/22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD test guideline 404. GLP
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source:Harlan UK Ltd
Number of Animals: Three
Age at study initiation: Approximately 13 weeks
Weight at study initiation: 2.7-3.2 kg
Housing: Individually
Diet (e.g. ad libitum): Special Diet Service STANRAB SQC (pellets); ad libitum
Water (e.g. ad libitum): Automatic watering system, ad libitum
Acclimation period: 22d
ENVIRONMENTAL CONDITIONS
Temperature (°C): 18-21
Humidity (%): 53-65%
Photoperiod (hrs dark / hrs light): 12/12
Monitored at least once a day - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Amount(s) applied (volume or weight): 0.5 ml
Concentration (if solution): neat - Duration of treatment / exposure:
- Test material was administered to the clipped backs as a single dose introduced under a gauze patch (secured with non-irritating tape) and held in contact with the skin by means of a semi-occlusive dressing for 4 hours. Residual test material was then removed.
- Observation period:
- 24, 48, and 72h post application and once per day until Day 14
- Number of animals:
- Three females
- Details on study design:
- SCORING SYSTEM: Draize scale for dermal irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Max. score:
- 2
- Reversibility:
- fully reversible within: 13 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1.3
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Topical application of Petrepar 134 (50/50) elicited dermal responses in all animals. Well defined erythema and slight edema followed exposure and was resolved by day 13.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The average erythema score (24,48, and 72 hours) was 1.9, with 2 out of 3 animals having a mean (24-72 hour) erythema score of 2.0. The average edema score (24,48, and 72 hours) was 1.1. Based on the individual animal dermal irritation scores, classification as a dermal irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Executive summary:
In this study, 3 rabbits were subjected to a 4h dermal (shaved) exposure of 0.5 ml of Petrepar 134 (50/50) via a semi-occluded patch. Dermal responses were evaluated at 1, 24, 48, and 72h post-dosing and once a day for a total of 14 days according to the Draize method of scoring. Topical application of Petrepar 134 (50/50) elicited dermal responses in all animals. Well defined erythema and slight oedema followed exposure and was resolved by day 13. The average erythema score (24,48, and 72 hours) was 1.9, with 2 out of 3 animals having a mean (24-72 hour) erythema score of 2.0. The average edema score (24,48, and 72 hours) was 1.1. Based on the individual animal dermal irritation scores, the test substance warrants classification as a dermal irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1997/04/27- 1997/07/23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 404: GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- six animals
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd
- Age at study initiation: adult
- Housing: individually
- Diet (e.g. ad libitum): Special Diets Services
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-19
- Humidity (%): 50-53
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Dermal responses were evaluated approximately 60 minutes, 24, 48, and 72 hours following patch removal.
- Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: dorsal surface from the shoulder region to the lumbar region
- % coverage: N/A
- Type of wrap if used: under a gauze patch secured with tape, the patch was loosely held in contact with the skin by means of a semi-occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): removed residual test material using reverse osmosis water and paper towels.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.55
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: based on scores of three animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The mean erythema and edema scores for the test material were 0.55 and 0.66 respectively. Classification as a dermal irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Executive summary:
The test material was administered via semi-occlusive patch for four hours to three rabbits (3 female) to assess dermal irritation Dermal responses were evaluated at 1, 24, 48, and 72h post-dosing according to the Draize method of scoring. Application of the test material elicited responses in all animals. Erythema scores decreased as the study progressed. Effects continued to subside until all animals were free of adverse clinical signs by study termination (Day 7). Classification as a dermal irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Irritation parameter | Basis | Time Point | Score | Reversibility |
erythema score | animal #1 | 24 hours | 1 | Fully reversible by 72 hours |
erythema score | animal #2 | 24 hours | 1 | Fully reversible by 72 hours |
erythema score | animal #3 | 24 hours | 1 | Fully reversible by 72 hours |
erythema score | animal #1 | 48 hours | 1 | Fully reversible by 72 hours |
erythema score | animal #2 | 48 hours | 1 | Fully reversible by 72 hours |
erythema score | animal #3 | 48 hours | 0 | Fully reversible by 72 hours |
erythema score | animal #1 | 72 hours | 0 | Fully reversible by 72 hours |
erythema score | animal #2 | 72 hours | 0 | Fully reversible by 72 hours |
erythema score | animal #3 | 72 hours | 0 | Fully reversible by 72 hours |
erythema score | mean | 24 hour mean | 1 | Fully reversible by 72 hours |
erythema score | mean | 48 hour mean | 0.66 | Fully reversible by 72 hours |
erythema score | mean | 72 hour mean | 0 | Fully reversible by 72 hours |
erythema score | mean | 24-72 hour mean | 0.55 | Fully reversible by 72 hours |
edema score | animal #1 | 24 hours | 2 | Fully reversible by 72 hours |
edema score | animal #2 | 24 hours | 1 | Fully reversible by 72 hours |
edema score | animal #3 | 24 hours | 1 | Fully reversible by 72 hours |
edema score | animal #1 | 48 hours | 1 | Fully reversible by 72 hours |
edema score | animal #2 | 48 hours | 1 | Fully reversible by 72 hours |
edema score | animal #3 | 48 hours | 0 | Fully reversible by 72 hours |
edema score | animal #1 | 72 hours | 0 | Fully reversible by 72 hours |
edema score | animal #2 | 72 hours | 0 | Fully reversible by 72 hours |
edema score | animal #3 | 72 hours | 0 | Fully reversible by 72 hours |
edema score | mean | 24 hour mean | 1.3 | Fully reversible by 72 hours |
edema score | mean | 48 hour mean | 0.66 | Fully reversible by 72 hours |
edema score | mean | 72 hour mean | 0 | Fully reversible by 72 hours |
edema score | mean | 24-72 hour mean | 0.66 | Fully reversible by 72 hours |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000/03/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 405: GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd
- Age at study initiation: 13 weeks
- Weight at study initiation: 2.7 - 3.2 kg
- Housing: individual
- Diet (e.g. ad libitum): Special Diet Services STANRAB SQC pellet, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 25 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 -23
- Humidity (%): 36-45
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye
- Amount / concentration applied:
- 0.1mL
- Duration of treatment / exposure:
- The eyelids were gently held together for one second before releasing.
- Observation period (in vivo):
- 1, 24, 48, and 72 hours post-treatment
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Test material was applied to the eyes and the eyelids were gently held together for one second before releasing. Irritation and toxicity were monitored at 1, 24, 48, and 72 hours post-treatment. Irritation was scored according to the Draize methodology.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No corneal damage or iridial inflammation was observed. Hyperaemia of blood vessels of the conjuctivae was seen in all animals. Ocular reactions had resolved in all instances by one day after instillation.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The mean conjunctivae, chemosis, iris, and cornea scores for the Petrepar 134 (60/40) were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Executive summary:
Petrepar 134 (60/40) (0.1 mL, neat) was administered to the right eye of three rabbits to assess occular irritation. Irritation and toxicity were monitored at 1, 24, 48, and 72 hours post-treatment. Irritation was scored according to the Draize methodology. No corneal damage or iridial inflammation was observed. Hyperaemia of blood vessels of the conjuctivae was seen in all animals. Ocular reactions had resolved in all instances by one day after instillation. The mean conjunctivae, chemosis, iris, and cornea scores for the Petrepar 134 (60/40) were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Referenceopen allclose all
Irritation parameter | Basis | Time Point | Score |
conjuctivae score | animal #1 | 24 hours | 0 |
conjuctivae score | animal #2 | 24 hours | 0 |
conjuctivae score | animal #3 | 24 hours | 0 |
conjuctivae score | animal #1 | 48 hours | 0 |
conjuctivae score | animal #2 | 48 hours | 0 |
conjuctivae score | animal #3 | 48 hours | 0 |
conjuctivae score | animal #1 | 72 hours | 0 |
conjuctivae score | animal #2 | 72 hours | 0 |
conjuctivae score | animal #3 | 72 hours | 0 |
conjuctivae score | mean | 24 hour mean | 0 |
conjuctivae score | mean | 48 hour mean | 0 |
conjuctivae score | mean | 72 hour mean | 0 |
conjuctivae score | mean | 24-72 hour mean | 0 |
chemosis score | animal #1 | 24 hours | 0 |
chemosis score | animal #2 | 24 hours | 0 |
chemosis score | animal #3 | 24 hours | 0 |
chemosis score | animal #1 | 48 hours | 0 |
chemosis score | animal #2 | 48 hours | 0 |
chemosis score | animal #3 | 48 hours | 0 |
chemosis score | animal #1 | 72 hours | 0 |
chemosis score | animal #2 | 72 hours | 0 |
chemosis score | animal #3 | 72 hours | 0 |
chemosis score | mean | 24 hour mean | 0 |
chemosis score | mean | 48 hour mean | 0 |
chemosis score | mean | 72 hour mean | 0 |
chemosis score | mean | 24-72 hour mean | 0 |
cornea score | mean | 24-72 hour mean | 0 |
iris score | mean | 24-72 hour mean | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no skin or eye irritation data available for Hydrocarbons, C11-C12, n-alkanes, <2% aromatics. However, data is available for structural analogue Hydrocarbons, C11-C14, n-alkanes, <2% aromatics and presented in the dossier. Additionally, an eye irritation study in humans is available from structural analogue, Decane. This data is read across to Hydrocarbons, C11-C12, n-alkanes, <2% aromatics based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Skin Irritation
Hydrocarbons, C11-C14, n-alkanes, <2% aromatics
In a key study (Cepsa Quimica, 2000), 3 rabbits were subjected to a 4h dermal (shaved) exposure of 0.5 ml of test material (Hydrocarbons, C11-C14, n-alkanes, <2% aromatics) (50/50) via a semi-occluded patch. Dermal responses were evaluated at 1, 24, 48, and 72h post-dosing and once a day for a total of 14 days according to the Draize method of scoring. Topical application of test material (50/50) elicited dermal responses in all animals. Well defined erythema and slight oedema followed exposure and was resolved by day 13. The average erythema score (24,48, and 72 hours) was 1.9, with 2 out of 3 animals having a mean (24-72 hour) erythema score of 2.0. The average edema score (24,48, and 72 hours) was 1.1. Classification as a dermal irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
In a key study (Petrochem Carless Limited, 1997), the test material (Hydrocarbons, C11-C14, n-alkanes) was administered via semi-occlusive patch for four hours to three rabbits (3 female) to assess dermal irritation. Dermal responses were evaluated at 1, 24, 48, and 72h post-dosing according to the Draize method of scoring. Application of the test material elicited responses in all animals. Erythema scores decreased as the study progressed. Effects continued to subside until all animals were free of adverse clinical signs by study termination (Day 7). Classification as a dermal irritant is not warranted under Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Ocular Irritation
Hydrocarbons, C11-C14, n-alkanes, <2% aromatics
In a key study (Cepsa Quimica, 2000), the test material (Hydrocarbons, C11-C14, n-alkanes, <2% aromatics) (60/40) (0.1 mL, neat) was administered to the right eye of three rabbits to assess ocular irritation. Irritation and toxicity were monitored at 1-, 24-, 48-, and 72-hours post-treatment. Irritation was scored according to the Draize methodology. No corneal damage or iridial inflammation was observed. Hyperaemia of blood vessels of the conjuctivae was seen in all animals. Ocular reactions had resolved in all instances by one day after instillation. The mean conjunctivae, chemosis, iris, and cornea scores for the test material (60/40) were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Decane
In a supporting dose-response study (Kjaergaard et al., 1989) of human reactions to the indoor air pollutant n-decane was performed in a climate chamber. Sixty-three healthy subjects, randomly selected from the normal population, were exposed to n-decane concentrations of either 0, 10, 35, or 100 uL/L in a controlled, double blind study using a Latin square exposure design. The most significant findings were dose-dependent changes in irritation of mucous membranes, increased sensation of odor intensity, and reduced air quality. Adaptation was seen at the highest exposure levels, but not at the levels relevant for a non-industrial environment. The physiological measurements showed decreased tear film stability at all exposure concentrations. The number of conjunctival polymorphonuelear leucocytes increased in a dose-related manner. Predictors of the sensitivity to exposure, i.e. mucous membrane irritation threshold and skin irritation (Stingers test), were correlated to subjective ratings of odor intensity and irritation of mucous membranes.
Respiratory Irritation
No studies were located to indicate that Hydrocarbons, C11-C12, n-alkanes, <2% aromatics is a respiratory irritant.
Justification for classification or non-classification
Skin Irritation:
Based on available read across data, Hydrocarbons, C11-C12, n-alkanes, <2% aromatics does not meet the criteria for classification for skin irritation under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Ocular Irritation:
Based on available read across data, Hydrocarbons, C11-C12, n-alkanes, <2% aromatics does not meet the criteria for classification as an ocular irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Respiratory Irritation:
There are no studies that warrant classification as a respiratory irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.