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EC number: 427-370-1 | CAS number: 164288-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The aim of this study was to assess the log Kow of the test substance:
The chemical substance is expected to exhibit the properties of a surfactant in the octanol-water system, which means that measurement by the shake-flask method is not possible. Also, estimation by high-performance liquid chromatography (HPLC) is not possible, primarily because cationic surfactants interact with HPLC columns by forces other than partition. Furthermore, little valid reference data exist for cationic surfactants, and hence HPLC estimation would be very unreliable.
The ratio of the solubility of the test substance in octanol to its solubility in water would not be a valid estimation method, due to the self-aggregation properties of a surfactant.
The conventional method to estimate Kow of organic compounds without requiring a laboratory study is by a fragment addition method. The method used was the KOWWIN program of Howard and Meylan. The lack of valid reference data for surfactants limits the extent of validation of an estimate, but does not make it impossible.
The KOWWIN program is the most modern program of its type, and has been fully described in the literature (P.H. Howard, WM Meylan, J Pharm, Sci., 84(1) 83-92, 1995). Its ability to predict log Kow is superior tto that of the program CLOGP (which is based on the Hansch and Leo method, and described in OECD Method 117). The two programs differ in the way that molecular fragments are defined. The method is first validated then applied to the test substance. Validation of an estimation method relies upon the availability of appropriate substances of known log Kow for inclusion in the debelopment of the method. In the case of the present substance it is considered that the following structural types should be examined:
1. the tetra-substitued ammonium group
2. a long chain amide, or acid if there is unsufficient litterature for amides
3. substitued amides
4. the hydroxy group attached to two methylene groups the hydroxyde or chloride counter ion is not considered to be significant in determining the partition coefficient. A lipophilic anion would exert a significant effect, but chloride and hydroxyde are not lipophilic.
The values of Kow are moderately Iow, suggesting that it will not have strong affinity for organic matter in soil or in organisms. However, its known surfactant properties may also exert an unknown influence on its uptake and adsorption.
For ecotoxicological purposes, the value of -0.09 should be taken then.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.09
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.