Registration Dossier
Registration Dossier
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EC number: 224-594-8 | CAS number: 4422-95-1
Endpoint summary
Administrative data
Description of key information
Skin Irritation/Corrosion: the substance is a strong acid (pH ≤ 2.0 in water) and the substance is considered to be skin corrosive
Eye Damage/Irritation: the substance is a strong acid (pH ≤ 2.0 in water) and the substance is considered to to cause irreversible eye damage
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 8.1 the study for skin corrosion/irritation in vitro, does not need to be conducted since the substance is classified as corrosive to the skin and/or the substance is a strong acid (pH ≤ 2.0 in water). The substance is classified under Regulation (EC) 1272/2008: Skin Corrosive: category 1. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.2.2, July 2017) the study does not need to be conducted. - Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
- the study does not need to be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5) and the available information indicates that it should be classified as serious eye damage (Category 1)
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 8.2, the study for serious eye damage/eye irritation in vitro, does not need to be conducted since the substance is a strong acid (pH ≤ 2.0 in water) and/or the substance is classified under Regulation (EC) 1272/2008: Skin Corrosive: category 1 thereby leading to classification as serious eye damage (Category 1). According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.2.7, July 2017) the study does not need to be conducted. - Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation/Corrosion:
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 8.1 the study for skin corrosion/irritation in vitro, does not need to be conducted since the substance is classified as corrosive to the skin and/or the substance is a strong acid (pH ≤ 2.0 in water). The substance is classified under Regulation (EC) 1272/2008: Skin Corrosive: category 1. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.2.2, July 2017) the study does not need to be conducted.
Eye Damage/Irritation:
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 8.1 the study for skin corrosion/irritation in vitro, does not need to be conducted since the substance is classified as corrosive to the skin and/or the substance is a strong acid (pH ≤ 2.0 in water). The substance is classified under Regulation (EC) 1272/2008: Skin Corrosive: category 1. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.2.2, July 2017) the study does not need to be conducted.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
