Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-211-1 | CAS number: 13236-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- During the test period, the temperature and humidity of the animal room were recorded with measured data every 1 hours by an automatic temperature and humidity meter in every 5 min intervals.
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- up to 72 hr
- Observation period:
- 3 min, 1, 4, 24, 48 and 72 hr
- Number of animals:
- 3
- Details on study design:
- 1. Room No.: Rabbit room 1
2. Cage type and size: Stainless steel cages (W 420 x L 270 x H 180 mm)
3. Animals per cage: 1 animal
4. Temperature: 18.1 ~ 20.6ºC
5. Relative humidity: 49.1 ~ 60.2%
6. Air exchange: 10 ~ 15 / hr
7. Light cycle: 12 hr light / 12 hr dark
8. Illumination: 150 ~ 300 lux - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- 1. As a result of observing the test substance administration site, skin irritation and corrosiveness were not observed in all the test substance the administration and control sites.
2. Evaluation of skin irritation scores at 24, 48 and 72 hours after administration of test substance resulted in a skin irritation score of "0.0" for erythema & edema and edema in all animals. - Other effects:
- 1. No mortality was observed in this study.
2. No treatment-related clinical signs were observed in any treated animals.
3. All tested animals observed normal gains in body weights. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- It was judged that it was not classified as according to CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- 1. Select reason test system
NZW rabbit is commonly used for this type of acute eye irritation and corrosion study for several decades and accumulated enough raw data to be compared and easy to be interpreted of experimental results.
2. Quarantine and Acclimation
The animals were examined for quarantine on the receipt and acclimatized to the Centralbio Animal Breeding Room for 5 days. Four healthy animals were selected and used for the study based on general health conditions.
3. Animal and cage identification
The animals was marked in the ear pinna using a permanent marker and identification cards was attached to each cage for an individual discrimination. - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- it indicated after 72 hours.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Reversibility:
- not fully reversible within: 20 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 15 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 6 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 6 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 6 d
- Irritant / corrosive response data:
- After 3 minutes of the initial test administration, no significant eye injury was observed as a result of observing the test substance administration site. Therefore, three additional animals were used for the confirmation test. As a result of observing the test substance administration sites at 1, 24, 48 and 72 hours after the test substance administration in the initial test and confirmation test, iris hyperemia was observed as 1 point in all cases at form 24 hours to 48 hours, 1 case was recovered at 72 hours and observed as 1 point in 3 cases. Observed iris hyperemia was recovered in 2 cases on the day 4 and 1 case on the day 16. Conjunctival redness was observed as 2 points in 2 cases at 1 hour and as 3 point in all cases at 24 hours, as 2 points in all cases at from 48 hours to 72 hours. Observed conjunctival redness was recovered as 3 cases on the day 9 and as 1 case on the day 21. Conjunctival swelling was observed as 2 points in all cases at from 1 hour to 72 hours. Observed conjunctival swelling was recovered as 3 cases on the day 7 and as 1 case on the day 16. Lacrima was observed as 2 points in all cases at from 1 hour to 24 hours and as 1 point in all cases at from 48 hours to 72 hours. Observed Lacrima was recovered as all cases on the day 6. In addition, corneal opacity was observed in 1 cases on day 4 and was not recovered until 21 days. No specific symptoms were observed in the cornea, iris, and conjunctiva in the left eye.
- Other effects:
- 1. Mortality and Clinical Signs
No clinical sign and mortality was observed relating to test substance treatment.
2. Body Weights
All the animals showed normal gains in body weights during the study period. - Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- As a result, eye irritation and corrosion test of eye of female NewZealand White rabbits of 1,2,3-tris(2,3-epoxypropoxy)propane under the test conditions showed that the turbidity of the cornea was not recovered until 21 days after administration of the test substance. It is solted to "Category 1" in the classification according to CLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.