Cyclooctane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-04-29 - 2021-05-31

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

European Commission Regulation (EC) No. 440/2008 and No. 260/2014

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

< 1.44 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

pH:

5.7

Three preliminary tests were carried out with specified amounts of the test item and 100 mL and 500 mL demineralized water, respectively. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles.

 

 

Table: Results of the preliminary test

Amount of test item /mg	Total volume of demineralized water / mL	Appearance of mixture
11.1	100	slightly turbid
10.2	500	no turbidity visible
4.8	500	no turbidity visible

 

 

The test item was a colourless liquid and the initial weights for the preliminary test were low. Therefore, the water solubility of the test item was difficult to determine visually in the preliminary test. The preliminary test showed only that the water solubility of the test item < 111 mg/L. However, due to the physical state of the test item (liquid) only the flask method was applicable in the main test.

 

 

 

Flask method

The flask method was performed as described. The data for the evaluation are given in the table. After the equilibration time precipitate was observed in the flasks of the experiments excluding in the blank experiment. The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in the table.

 

Experiment	24 h experiment	48 h experiment	72 h experiment	Blank experiment 72 h
Amount of test item / mg	59.8	59.8	60.6	-
Amount of demineralized water / mL	100	100	100	100
Stirring at 30 °C / h	24	48	72	72
pH at ambient temperature	5.7	5.7	5.7	5.7
Dilution Factor	4	4	4	4
Measured concentration /mg/L	<0.36/<0.36	<0.36/<0.36	<0.36/<0.36	-/-
Mean concentration /mg/L	<0.36	<0.36	<0.36	-
Water solubility / mg/L	1.44	1.44	1.44	-

 

The content of the test item found in the GC analysis was below the quantification limit of 1.44 mg/L of the GC calibration. Therefore, the water solubility of the test item at 20 °C was determined to be below 1.44 mg/L.

Conclusions:

The water solubility cs of the test item at a temperature of 20 °C was determined according to the flask method. It was found to be < 1.44 mg/L.

Executive summary:

The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The column elution method showed a solubility: cs < 1.44 mg/L.

Description of key information

The column elution method showed a water solubility: cs < 1.44 mg/L (reference 4.8-1).

Additional information

The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The column elution method showed a solubility: cs < 1.44 mg/L.