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EC number: 269-847-3 | CAS number: 68345-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-11-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,7-dimethyloct-1-en-3-ol
- EC Number:
- 242-358-2
- EC Name:
- 3,7-dimethyloct-1-en-3-ol
- Cas Number:
- 18479-49-7
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- -Animal Breeder: DR. K. THOMAE GMBH, D-7950 BIBERACH, FRG
-Type of cage: STAINLESS STEEL WIRE MESH CAGES,TYPE DK-III ( BECKER & CO., CASTROP-RAUXEL . FRG )
-Acclimatization period: at least for 1 week
-No. of animal per cage: 5
-Animals were housed in fully air-conditioned rooms. Temperature range: 20 - 24 Celsius degrees. Relative humidity: 30 - 70%. There were no deviations from these ranges which influenced the results of the study.
-Day/Night rhythm: 12 h/12 h (6 am - 6 pm/ 6 pm - 6 am)
-Diet: Kliba-Labordiaet 343, klimgentalmuehle AG CH-4303 Kaiseraugst, Switzerland, ad libitum
Drinking water: Tap water, ad libitum
Animal weights: animal of comparable weight (+/- 20% of the mean weight)
Feed was not provided to the animals starting from 16 hours before administration but water was maintained available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Reason for the vehicle: aqueous formulation corresponds to the physiological medium
Form of the administration: emulsion
Time of the day for the administration: in the morning - Doses:
- Dose (mg/kg): 2000
Concentration (g/100 mL - w/v): 20
Administration volume (mL/kg): 10 - No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Signs and symptons: Recording of signs and symptoms several times on the day of administration, at least once each workday, check for moribund and dead animals twice each workday and once on holidays.
Pathology: Withdrawal of food about 16 h before sacrifice with CO2, then necropsy with gross-pathological examination
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalitiy occured.
Dead animals after 14 days: 0
Mortality: 0 % - Clinical signs:
- other: other:
- Gross pathology:
- No pathological findings noted.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No animal deceased in consequence of the single treatment with the test substance at a dose level of 2000 mg/kg bw via gavage, therefore no LD50 could be determined and is therefore assumed to be >2000 mg/kg bw.
- Executive summary:
For the estimate of potential acute hazard after single administration of DMOE-acetate, 5 Wistar-rats of each sex were treated by gavage with 2000 mg/kg bw/d of the test item, formulated in carboxymethyl cellulose. The treatment was followed by an observation period of 14 days and a necropsy with gross pathological examination after completion. No mortality occured during the observation period and no gross pathological findings were noted.
Due to no mortality no LD50 could be determined and was assumed to be >2000 mg/kg bw/d.
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