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EC number: 260-300-4 | CAS number: 56634-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-29 May 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 0.16 mg/L
- Temp.:
- 20 °C
- pH:
- 6.9
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 23 Dec 1992 - 22 Apr 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- no preliminary testing
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 0.17 mg/L
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: temperature reported as ambient (20-25 °C)
- Water solubility:
- 0.08 mg/L
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: temperature reported as ambient (20-25 °C)
- Water solubility:
- 0.15 mg/L
- Temp.:
- 20 °C
- pH:
- 9
- Remarks on result:
- other: temperature reported as ambient (20-25 °C)
Referenceopen allclose all
Preliminary test:
Even in a total volume of 1000 mL added to ca. 10 mg of the test item, still undissolved particles could be observed after 96 h. This result indicated that the water solubility of the test item was probably below 10 mg/L. Therefore the column elution method was chosen for the study.
Preparation of the column and sample preparations for runs 1, 2, 3:
The following amounts of the test item were weighed into a round bottom flask: RUN 1 = 42.0 mg / RUN 2 = 53.8 mg / RUN 3 = 51.3 mg. Approximately 2.5 g of glass beads (2 mm in diameter) were added and then the test item was dissolved in some drops of acetonitrile. Then the solvent was removed using a nitrogen stream while the flask was shaken carefully. The dry coated glass beads were placed into the distilled water containing column of the test apparatus (column temperature: 20°C, bidistilled water at room temperature: measured pH = 6.9). After a minimum swelling time of approximately 2 h, the pump was started. The fractions were collected using test tubes.
To ensure the stability of the fractions during the sampling period all test tubes provided for the HPLC measurement were prepared with 50 µL of a 0.1 M H3PO4 solution prior to the start. The test tubes for pH measurement were left blank.
The volume of the collected aqueous fractions was estimated and the pH at room temperature was measured in each fifth test tube. 10 mL of each fraction were added with 2 mL of acetonitrile to a total volume of 12 mL (5 mL per fraction + 1 mL acetonitrile for RUN 3) and then analysed by HPLC. The concentration of the test item in the individual fractions was determined by HPLC.
Individual conditions and results:
Run (flow rate) |
Rotation period of the fraction collector |
Flow rate, measured |
Average fraction volume (calc.) |
Duration of sampling |
Average solubility (mg/L) (RSD) |
Remarks |
Run 1 (25 mL/h) |
35 min per fraction |
25.3 mL/h |
14.8 mL |
Approx. 14.6 h |
0.154 (5.8%) |
Fractions 6 to 9 and 11 to 14 of 25 in total. The solubility varied between 0.140 and 0.164 mg/L. |
Run 2 (12.5 mL/h) |
66 min per fraction |
12.7 mL/h |
14.0 mL |
Approx. 22 h |
0.167 (2.4%) |
Fractions 6 to 9 and 11 of 20 in total. The solubility varied between 0.163 and 0.174 mg/L. |
Run 3 (6.25 mL/h) |
99 min per fraction |
6.24 mL/h |
10.3 mL |
Approx. 33 h |
0.148 (2.7%) |
Fractions 7 to 9, 11 to 14 and 16 to 17 of 20 in total. The solubility varied between 0.142 and 0.154 mg/L. |
Kryostat error began with fraction 12 of Run 2. Therefore temperature control was not ensured for samples beginning with fraction 12. Room temperature for those fractions was approximately 26 °C. In consequence Run 3 was performed with a flow rate of 6.25 mL/h.
Coating check
At the end of each column elution experiment it was confirmed that there was still enough test item on the elution columns. Therefore the residual test item was eluted completely from the column into a 100 mL volumetric flask using acetonitrile. An aliquot (1.0 mL) of this solution was filled up with the HPLC eluent to a volume of 50 mL for Run 1 (100 mL for Run 2 and Run 3) and analyzed by HPLC. The results below show that there was a sufficient amount of test item on the column in order to ensure the saturation of the eluted aqueous phase.
Sample |
Amount used for coating (mg) |
Concentrate of eluate solution (mg/L) |
Amount of residual test item found (mg) |
Mean amount needed for the saturation of one fraction (µg) |
Theoretical number of fractions to be saturated by residual amount |
Run 1 |
42.0 |
133.2 |
13.3 |
2.28 |
5833 |
Run 2 |
53.8 |
329.9 |
33.0 |
2.12 |
15566 |
Run 3 |
51.3 |
262.5 |
26.3 |
0.92 |
28587 |
Description of key information
0.16 mg/L at 20 °C, pH 6.9 (EU A.6, OECD 105, column elution method)
Key value for chemical safety assessment
- Water solubility:
- 0.16 mg/L
- at the temperature of:
- 20 °C
Additional information
In an earlier experiment, conducted according to OECD 105 (column elution method), the following results were obtained at 20 °C: 0.17 mg/L (pH 5), 0.08 mg/L (pH 7), 0.15 mg/L (pH 9). They are supporting.
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