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EC number: 295-155-6 | CAS number: 91844-86-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Artemisia pallens, Compositae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09/15 February 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP study carried out according to OECD / EU guidelines.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 15/16 Nov. 2017, signed on 15 May 2018
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- Appearance: yellow to red, clear liquid
Storage room temperature: 20 ± 5 °C (293.15 ±5 K) - Key result
- Boiling pt.:
- ca. 205.26 °C
- Atm. press.:
- ca. 1 011.9 mBar
- Conclusions:
- Under the test conditions, at the pressure of 1011.9 mBar, the mean onset for boiling occurred at 205.26°C (478.41 K).
- Executive summary:
The boiling point of the test substance was determined under GLP according to OECD 103 / EU A.2 guideline, using differential scanning calorimetry (DSC) method.
Two main runs were performed under inert gas atmosphere at the pressure of 1011.9 mBar, and the mean temperature was retained.
In all runs one event was detected. The event is endotherm and is stated as the boiling point.
Under the test conditions, at the pressure of 1011.9 mBar, the mean onset for boiling occurred at 205.26°C (478.41 K).
Reference
Results Pre-Test:
All observations of the Pre-Test for Boiling Point and Safety Test are presented in the following tables:
Table 1 Pre-Test for Boiling Point and Safety Test
Observations | Temperatures in °C |
Individual bubble | from 51 |
Condensate was visible | from 76 |
More condensate | from 110 |
Bubbles came faster | from 160 |
Bubble chain began with boiling delay, fizzle and gas in head space, for safety reasons the heating plate was turned off | 210 |
The test item was visually unchanged | after cooling down |
Security test for the DSC instrument:
The crucible was found visually unchanged after reaching a temperature of 200 °C, 300 °C,400 °C and 450 °C. The weight of the crucible was recorded with 45.17 mg (weight loss: 2.18 mg, i.e 89.3% of substance).
Table 2 - Values DSC Test Item Pre-Test
Boiling point | Temperature [°C] | Energy (J/g) / Heat flow (mW) |
Begin | 156.65 | 18.52 mW |
Onset | 205.77 | 193.41 J/g |
Peak max. | 277.43 | - |
End | 337.23 | 17.12 mW |
Table 3-Values Observations
Mass test item | Mass crucible (before measurement): | Mass crucible (after measurement): | Observations | |
DSC P re-test | 2.80 mg | 47.34 mg | 44.66 mg | After the test the crucible was visually unchanged (weight loss: 2.68 mg, i.e. : 95.7%) |
Results - Test Method following DSC (Main-test):
After calibration with indium and zinc the measurement of indium yielded the following values:
Table 4 - Values DSC Indium:
Expected Melting point | Measured Melting point | Expected Energy | Measured Energy | Assessment |
156.6 ± 1.0°C | 156.83 °C (onset) | 28.45 ± 1.0 J/g | 27.64 J/g | OK |
The ambient atmospheric pressure was recorded to be 1011.9 mbar.
Table 5 - Values DSC Test Item first determination
Boiling point | Temperature [°C] | Energy (J/g) / Heat flow (mW) |
Begin | 162.15 | 18.75 mW |
Onset | 205.12 | 158.28 J/g |
Peak max. | 284.26 | - |
End | 340.16 | 16.84 mW |
The ambient atmospheric pressure was recorded to be 1011.9 mbar
Table 6 - Values DSC Test Item second determination
Boiling point | Temperature [°C] | Energy (J/g) / Heat flow (mW) |
Begin | 162.15 | 18.88 mW |
Onset | 205.39 | 156.51 J/g |
Peak max. | 284.4 | - |
End | 340.14 | 16.87 mW |
Table 7 - Values Observations
Mass test item | Mass crucible (before measurement): | Mass crucible (after measurement): | Observations | |
First Measurement | 4.15 mg | 49.80 mg | 45.81 mg | After the test the crucible was visually unchanged (weight loss: 3.99 mg, i.e. : 96.1%) |
Second Measurement | 4.18 mg | 49.41 mg | 45.35 mg | After the test the crucible was visually unchanged (weight loss: 4.06 mg, i.e. : 97.1%) |
Table 8 - Presentation of Results:
All results are presented in the following table.
Boiling point | Temperature [°C] | Temperature [K] | |
1st Determination | Begin | 162.15 | 435.30 |
2nd Determination | Begin | 162.15 | 435.30 |
Mean | 162.15 | 435.30 | |
Sd | 0.00 | 0.00 | |
1st Determination | End | 340.16 | 613.31 |
2nd Determination | End | 340.14 | 613.29 |
Mean | 340.15 | 613.30 | |
Sd | 0.01 | 0.01 | |
1st Determination | Onset | 205.12 | 478.27 |
2nd Determination | Onset | 205.39 | 478.54 |
Mean | 205.26 | 478.41 | |
Sd | 0.19 | 0.19 | |
1st Determination | Peak max. | 284.26 | 557.41 |
2nd Determination | Peak max. | 284.40 | 557.55 |
Mean | 284.33 | 557.48 | |
Sd | 0.10 | 0.10 |
Description of key information
Under the test conditions, at the pressure of 1011.9 mBar, the mean onset for boiling occurred at 205.26°C (478.41 K).
Key value for chemical safety assessment
Additional information
A fully reliable experimental study, conducted according to a recognized OECD 103 / EU A.2 method and under GLP, is available.
It is considered as a key study, and the result is retained as key data.
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