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EC number: 827-772-9 | CAS number: 20650-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- direct peptide reactivity assay (DPRA)
Test material
- Reference substance name:
- (3-methoxypropyl)dimethylamine
- EC Number:
- 827-772-9
- Cas Number:
- 20650-07-1
- Molecular formula:
- C6H15NO
- IUPAC Name:
- (3-methoxypropyl)dimethylamine
Constituent 1
In chemico test system
- Details of test system:
- cysteine peptide, (Ac-RFAACAA-COOH)
- lysine peptide (Ac-RFAAKAACOOH)
- Details on the study design:
- The Direct Peptide Reactivity Assay was used to assess the skin sensitization potential of the test
article. Synthetic peptides containing cysteine or lysine were reacted with each test article for 24 ±
2 hours. After the incubation period, the extent of peptide depletion was analyzed using High Per
formance Liquid Chromatography (HPLC) coupled with ultra-violet (UV) spectrometric detection.
2 assays were performed. - Vehicle / solvent:
- acetonitrile
- Positive control:
- cinnamic aldehyde
Results and discussion
- Positive control results:
- Mean Peptide Depletion (%): 82.0 for Cysteine, 65.0 for Lysine
In vitro / in chemico
Resultsopen allclose all
- Key result
- Group:
- test chemical
- Run / experiment:
- mean
- Parameter:
- lysine depletion
- Value:
- 1.76 %
- At concentration:
- 100 mM
- Positive controls validity:
- valid
- Key result
- Group:
- test chemical
- Run / experiment:
- mean
- Parameter:
- cysteine depletion
- Value:
- 5.59 %
- At concentration:
- 100 mM
- Positive controls validity:
- valid
- Outcome of the prediction model:
- no or minimal reactivity [in chemico]
- Other effects / acceptance of results:
- The assay was accepted as the following criteria were met:
1) Each standard curve must have an r2 > 0.990 => criterion met
mean peptide concentration of reference controls A and C = 0.50 ± 0.05 mM => criterion met
peak area CV for reference controls B and C must be < 15% => criterion met
2) percent peptide depletion for cysteine peptide with positive control > 60.8% => criterion met
and SD for replicates < 11.6 => criterion met
percent peptide depletion for lysine peptide with positive control: 40.2 to 69.4% => criterion met
and SD for replicates < 11.6 => criterion met
3) SD of test substance replicates <11.6% for lysine/cysteine depletion => criterion met
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The test article, DMMOPA, was evaluated for skin sensitization potential using the
Direct Peptide Reactivity Assay (DPRA) in 2 assays. The % peptide depletion was 5.59% (Cysteine) and 1.76% (Lysine). Based on these results, DMMOPA was predicted to be a non-sensitizer.
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