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EC number: 266-257-8 | CAS number: 66215-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2003/05/22 to 2003/07/25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF Guideline, 12 Nohsan 8147
- Version / remarks:
- 2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
- EC Number:
- 266-257-8
- EC Name:
- N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
- Cas Number:
- 66215-27-8
- Molecular formula:
- C6H10N6
- IUPAC Name:
- N2-cyclopropyl-1,3,5-triazine-2,4,6-triamine
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
- other:
- Details on sampling:
- Duplicate irradiated and single dark control samples were removed after 0, 1, 3, 5, 8 10, 12 and 15 days and 0, 1, 3, 8 and 15 days of continuous irradiation/incubation.
- Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- 290 - < 800
- Details on light source:
- Xenon Burner: Max. 765 W/m2 at max. UV filtering (lambda < 800 nm) with controllable irradiance between 400 W/m2 and 765 W/m2 to a pre— set value.
Filters: UV filter with a 290 nm cut-off to simulate natural sunlight.
Exposure Area: Approximately 500 cm2
Light Intensity: Determined with a LI-1800 spectrophotometer (44 W/m2)
Reaction Vessel Area: 3.5 cm2 the test vessels were positioned in the centre of the irradiated area.
The spectral energy distribution of the Xenon burner measured through the borosilicate glass
lids and of the sun, measured from 300 to 800 nm
- Details on test conditions:
- The test item was exposed to light in 25 ml incubation tubes (inner diameter 2.1 cm, height 11.0 cm, exposed area 3.5 cm2) constructed entirely of glass (see Figure 1) and covered with borosilicate lids which absorbs radiation below 290 nm similarly to the natural sunlight cut—off by ozone. The solutions were continuously illuminated through their borosilicate lids and stirred using magnetic stirrers.
Filtered, humidified air was drawn through the incubation vessels over the solutions at about 10 mL/minute. Any radioactive carbon dioxide or organic volatiles in the purged air was captured in traps of ethylene glycol followed by 2M NaOH, respectively. In addition to the irradiated samples, individual aliquots of 15 ml sterilized pond water were incubated under identical conditions in the dark using the same vessels as for the irradiated solution (dark control).
Duration of test at given test condition
- Duration:
- 15 d
- Temp.:
- 26 °C
- Initial conc. measured:
- 1.761 mg/L
- Reference substance:
- no
Results and discussion
% Degradationopen allclose all
- Key result
- Test condition:
- Irradiated
- Test condition:
- Dark covered soil
- Test condition:
- Non-extractables were observed in the 0 h samples ranging from 7 % in the moist to 13 % in the dry soil, whereas the corresponding amounts of Cyromazine were 93 and 86 %.
- Test condition:
- After 24 hours of exposure, the moist covered and exposed soil samples contained 68 and 71 % of CGA 72 662, respectively. The corresponding values for the dry soil samples were found to be 72 and 78 %, respectively .
- Transformation products:
- no
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results clearly showed that no significant photodegradation of Cyromazine in sterilised natural pond water.
- Executive summary:
The photochemical degradation of cyromazine was investigated under simulated sunlight in sterilised natural pond water at pH 8.7. Simulated sunlight from a “Suntest” apparatus equipped with a 1.8 kW xenon arc lamp, withfilters to remove wave lengths below 290 nm, was used to irradiate individual samples of cyromazine in sterile pond water at an initial concentration of 1.761 mg/L and maintained at a mean temperature of 26.0 ± 0.6°C.
The intensity of the lamp was slightly higher (44.6 than that of natural daylight (37.6 W/m2) measured at the same time in the spring with the same spectrophotometer at RCC Ltd. facility, 47.5°N latitude. The irradiation was for a continuous period of 15 days. Control samples were incubated under the same conditions but in the dark. Samples were taken for analysis at intervals up to 15 days with radiochemical quantification by liquid scintillation counting (LSC) and chromatographic analysis by high performance liquid chromatography (HPLC) and/or thin layer chromatography (TLC).
The total mean recoveries from the irradiated and dark control samples were 102.0% ± 2.2% and 103.3% ± 2.9% of the applied radioactivity, respectively, during the 15 day irradiation/incubation period. Under irradiated conditions, no significant photodegradation of cyromazine was observed. At the end of irradiation (day 15), cyromazine still accounted for 95.0% of the applied radioactivity (all percentages are given as mean values of replicates) with the samples showing no significant trend for degradation. For these reasons no degradation rates could be calculated for the test item and the DT 50 value was estimated to be > 100 “Suntest” days.
Since the experimental photolytic half life DT50 was estimated to be > 100 days under the “Suntest” artificial light conditions, the corresponding environmental photolytic half lives (DT50) at different latitudes (30°N to 50°N and for Tokyo, 35°N) were also estimated to be higher than 100 days (by a factor 3.0, 3.2, and 5.7 for 30-40 N, 50°N and Tokyo 35 °N respectively).
Up to four minor radioactive fractions were detected of which one (M1), was characterised as Melamin by co-chromatography with the unlabelled reference compound using HPLC and TLC analysis. M1 increased to a maximum of 2.4% of the applied radioactivity on day 15. The other photodegradates reached amounts up to 1.4% of the applied radioactivity (M4, day 1). Mineralisation of cyromazine was negligible throughout the irradiation period, with radioactive carbon dioxide never exceeding 0.1% of the applied radioactivity throughout the study. Cyromazine was stable in the dark control samples indicating that there was no hydrolysis during the study (102.1 % at day 15). The results therefore, showed that no significant photodegradation of cyromazine occurred in sterilised natural pond water.
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