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EC number: 292-960-4 | CAS number: 91031-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to Regulation (EC) No 1907/2006, Annex VIII, section 8.5, column 2, the information mentioned under 8.5.2 to 8.5.3 shall be provided for at least one other route in addition to the oral route (8.5.1) for substances other than gases. The choice for the second route will depend on the nature of the substance and the likely route of human exposure. Testing by the dermal route is appropriate if: (1) inhalation of the substance is unlikely; and (2) skin contact in production and/or use is likely; and (3) the physicochemical and toxicological properties suggest potential for a significant rate of absorption through the skin.
In consideration of the same section (Column 2 of Annex VIII, Section 8.5.3), testing by the dermal route does not need to be conducted if the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route, and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation) or, in the absence of an in vivo study by the oral route, no systemic effects after dermal exposure are predicted on the basis of non-testing approaches (e.g. read across, QSAR studies).
The target substance Fatty acids, C16-18, isononyl esters (CAS 91031-57-1) did not cause mortality or adverse clinical signs in an acute toxicity study following oral administration of 5000 mg/kg bw in male and female Wistar rats. Furthermore, no systemic effects were noted in vivo skin irritation and skin sensitisation studies performed with the analogue substances Fatty acids, C16-18, isotridecyl esters (CAS 95912-88-2), Decyl oleate (CAS 3687-46-5), 2-ethylhexyl oleate (CAS 26399-02-0), 2-octyldodecyl isooctadecanoate (CAS 93803-87-3), and Fatty acids, C16-18, 2-ethylhexyl esters (CAS 91031-48-0).
Workers are not exposed due to a closed process system. Professionals/consumers exposure is expected to be very low due to the concentration of <2% in the preparation and absence of acute oral toxicity. Acute dermal toxicity is not considered relevant since the concentration of the target substance in the preparation is <2% throughout the supply chain.
Therefore, testing acute dermal toxicity should be avoided for reasons of animal welfare, especially as the substance is not classified as STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure.
Data source
Materials and methods
Test material
- Reference substance name:
- Fatty acids, C16-18, isononyl esters
- EC Number:
- 292-960-4
- EC Name:
- Fatty acids, C16-18, isononyl esters
- Cas Number:
- 91031-57-1
- Molecular formula:
- not available - multi constituent substance
- IUPAC Name:
- Fatty acids, C16-18, isononyl esters
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.