2-tert-butyl-4-methoxyphenol

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various chemicals

Justification for type of information:

Experimental data of various chemicals from collection of data

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE was prepared for the determination of toxicity range of chemical on the growth of different microorganisms.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: Tetrahymena thermophile (Ciliate Protozoa)

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

no

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.55 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Population growth rate inhibition

Remarks on result:

other: 1st study

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.9 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Population growth rate inhibition

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

1: Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.55 mg/l.
2: Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.9 mg/l.

Executive summary:

Various studies available for the test chemical were reviewed to determine the toxic nature of test chemical on the population rate and growth of microorganisms. The studies are as mentioned below:

 

In the first study for test chemical toxicological study was conducted to determine the nature and effect of test chemical when comes in contact with the Tetrahymena Thermophile. Test performed for the total exposure period of 48 hrs. Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.55 mg/l. Based on the effect observed on the microorganisms, chemical was consider as toxic.

 

Above study was supported by the second supporting study from authoritative database 2018. Toxicological study was conducted to determine the nature and effect of test chemical when comes in contact with the Tetrahymena Thermophile. Test performed for the total exposure period of 48 hrs. Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.9 mg/l. Based on the effect observed on the microorganisms, chemical was consider as toxic.

 

Thus based on the above effects observed on microorganisms, toxicity ranges from 2.55 mg/l to 2.9 mg/l.

Description of key information

1: Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.55 mg/l.

2: Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.9 mg/l.

Thus based on the above effects observed on microorganisms, toxicity ranges from 2.55 mg/l to 2.9 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:

2.55 mg/L

Additional information

Various studies available for the test chemical and structurally and functionally similar read across chemicals were reviewed to determine the toxic nature of test chemical on the population rate and growth of microorganisms. The studies are as mentioned below:

 

In the first study for read across chemical toxicological study was conducted to determine the nature and effect of test chemical when comes in contact with the Tetrahymena Thermophile. Test performed for the total exposure period of 48 hrs. Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.55 mg/l. Based on the effect observed on the microorganisms, chemical was consider as toxic.

 

Above study was supported by the second supporting study from authoritative database 2018. Toxicological study was conducted to determine the nature and effect of test chemical when comes in contact with the Tetrahymena Thermophile. Test performed for the total exposure period of 48 hrs. Based on the effect observed on the Population growth rate inhibition of Tetrahymena thermophile (Ciliate Protozoa) during the exposure period of 48 hrs, the EC50 was determine to be 2.9 mg/l. Based on the effect observed on the microorganisms, chemical was consider as toxic.

 

Thus based on the above effects observed on microorganisms, toxicity ranges from 2.55 mg/l to 2.9 mg/l.