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EC number: 271-587-0 | CAS number: 68585-78-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant, guidline study with some deviations.
- Justification for type of information:
- Read across valid as the substnace tested is also titanate complex with alkylphosphate, degrading in water to form simple alcohols including 2-propanol and phosphate esters.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Principles of method if other than guideline:
- The test substance could not be verified as the susbtance hydrolyses rapidly on contact with water.
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- The pH and dissolved oxygen were measured at test initation and termination. The temperature was measured at 0, 24 and 48 hours. Daphnia immobilisation was measured at 24 and 48 hours.
- Vehicle:
- yes
- Details on test solutions:
- Test water: dechlorinated and aged laboratory tap water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus). Age: 1st instar. Source: laboratory culture originating from a strain supplied by IRCHA, France. Holding: 2L of dechlorinated and aged tap water in glass vessels. Temperature: 20 +/- 2°C. Feeding: mixture of commercial fry fish food and predominantly Chlorella spp. mixed algae. Reproduction: conditions ensured parthenogenesis. Selection: young Daphnids produced overnight from gravid adults isolated for 24 hours prior to testing were used.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Total hardness: c. 330 mg/L.
- Test temperature:
- 21 +/- 1°C. Temperature was 21.0°C at test initiation and at 24 hours. Temperature was 21.5°C at test termination.
- pH:
- The pH ranged from 7.8-8.1 at test initiation and was 8.0 at test termination.
- Dissolved oxygen:
- Not aerated. The dissolved oxygen was 8.9 mgO2/L at test initation and ranged from 8.0 to 8.6 mgO2/L at test termination.
- Salinity:
- Freshwater was used.
- Nominal and measured concentrations:
- 10 mg/L nominal
- Details on test conditions:
- Test containers: Glass vessels containing 200ml of test solution. Number of concentrations: 1 test solution and 1 control (including 100 mg/L auxillary solvent). Number of replicates per concentration: 2. Number of organisms per vessel: 10. Loading: 20 ml of test solution per organism. Photoperiod: 16h light: 8 h dark.
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No immobilisation occurred when Daphnids were exposed to a nominal concentration of 10 mg/L.
- Results with reference substance (positive control):
- No reference substance was used but no mortalities were seen in the control vessel which contained equivalent amounts of auxillary solvent.
- Reported statistics and error estimates:
- Nominal concentrations were not verified and were not expected to have been maintained due to the rapid hydrolysis of the test substance on contact with water. The low water solubility of the test substance and the limit of auxillary solvent as set out in the test guideline meant that no higher concentrations could be tested.
- Validity criteria fulfilled:
- no
- Remarks:
- The concentration of test substance could not be verified as the test substance hydrolyses rapidly on contact with water.
- Conclusions:
- No immobilisation occurred when Daphnids were exposed to a nominal concentration of 10 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18-20 March 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant, guidline study with some deviations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- The test substance could not be verified as the susbtance hydrolyses rapidly on contact with water.
- Principles of method if other than guideline:
- The test substance could not be verified as the susbtance hydrolyses rapidly on contact with water.
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- The pH and dissolved oxygen were measured at test initation and termination. The temperature was measured at 0, 24 and 48 hours. Daphnia immobilisation was measured at 24 and 48 hours.
- Vehicle:
- yes
- Details on test solutions:
- Test water: dechlorinated and aged laboratory tap water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus). Age: 1st instar. Source: laboratory culture originating from a strain supplied by IRCHA, France. Holding: 2L of dechlorinated and aged tap water in glass vessels. Temperature: 20 +/- 2°C. Feeding: mixture of commercial fry fish food and predominantly Chlorella spp. mixed algae. Reproduction: conditions ensured parthenogenesis. Selection: young Daphnids produced overnight from gravid adults isolated for 24 hours prior to testing were used.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Total hardness: c. 330 mg/L.
- Test temperature:
- 21 +/- 1°C. Temperature was 21.0°C at test initiation and at 24 hours. Temperature was 21.5°C at test termination.
- pH:
- The pH ranged from 7.8-8.1 at test initiation and was 8.0 at test termination.
- Dissolved oxygen:
- Not aerated. The dissolved oxygen was 8.9 mgO2/L at test initation and ranged from 8.0 to 8.6 mgO2/L at test termination.
- Salinity:
- Freshwater was used.
- Nominal and measured concentrations:
- 10 mg/L nominal
- Details on test conditions:
- Test containers: Glass vessels containing 200ml of test solution. Number of concentrations: 1 test solution and 1 control (including 100 mg/L auxillary solvent). Number of replicates per concentration: 2. Number of organisms per vessel: 10. Loading: 20 ml of test solution per organism. Photoperiod: 16h light: 8 h dark.
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No immobilisation occurred when Daphnids were exposed to a nominal concentration of 10 mg/L.
- Results with reference substance (positive control):
- No reference substance was used but no mortalities were seen in the control vessel which contained equivalent amounts of auxillary solvent.
- Reported statistics and error estimates:
- Nominal concentrations were not verified and were not expected to have been maintained due to the rapid hydrolysis of the test substance on contact with water. The low water solubility of the test substance and the limit of auxillary solvent as set out in the test guideline meant that no higher concentrations could be tested.
- Validity criteria fulfilled:
- no
- Remarks:
- The concentration of test substance could not be verified as the test substance hydrolyses rapidly on contact with water.
- Conclusions:
- No immobilisation occurred when Daphnids were exposed to a nominal concentration of 10 mg/L.
- Executive summary:
Douglas (1986) is a GLP-compliant, static study on Daphnia magna following OECD guideline 202. Nominal concentrations were not verified and were not expected to have been maintained due to the rapid hydrolysis of the test substance on contact with water. The low water solubility of the test substance and the limit of auxilary solvent as set out in the test guideline meant that no higher concentrations could be tested. These deviations were not expected to have affected the outcome of the results achieved and therefore the study is considered reliable and suitable for use for this endpoint.
Referenceopen allclose all
Description of key information
No study was conducted on the target substance. Read-across from structural analogue, Titanium butyl phosphate, is valid in that both substances are hydrolytically unstable and forms simple alcohols, including 2-propanol, and phosphate esters.
Based on the results of the structural analogue, no immobilisation occurred when Daphnia were exposed to a nominal concentration of 10 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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