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Diss Factsheets
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EC number: 807-421-6 | CAS number: 260359-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Test material form:
- liquid
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Purity : 96.8%
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- at the begin, 24 and 48 h
Test solutions
- Details on test solutions:
- Juvenile daphnids were exposed to an aqueous test medium containing the test item at five nominal concentrations in a geometric series (2.0, 6.3, 20.0, 63.2, 200.0 microg/l).
A solvent control was prepared by adding 50 microl acetone to 500 ml of reconstituted water in order to obtain the same solvent concentation of the test solution (100 ul).
A control with reconstituted water only was also tested.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- ACCLIMATION
- Acclimation period:12 days
- Acclimation conditions: same as test
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Check for immobilisation 24 and 48 h after test initiation
Test conditions
- Hardness:
- 2.5 mmol/L (250.0 mg/l as CaCO3)
- Test temperature:
- 20 +/-2°C with a maximum deviation of +/-1°C during the individual study. 19.0 - 21.0°C.
- pH:
- 7,32 - 7,72
- Dissolved oxygen:
- 6.1 - 7.0 mg/l
- Nominal and measured concentrations:
- 2.0, 6.3, 20.0, 63.2, 200.0 microg/l
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 16 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- IC50
- Effect conc.:
- 9.5 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Remarks on result:
- other: 7.5-10.5
- Details on results:
- The test item concentration was not stable during the test, the measured concentrations being around 55% and 20-40% of the nominal already short after being prepared (time 0 h and time 24 h, fresh solution rescpectively), while further decrease occurrred during the following day (to around 3-30 % of the nominal). Therefore the biological results are not referred to the nominal concentration but to the geometric mean of the measured concentration.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results, calculated based on the mean of the measured exposure concentrations were as follows:
48h NOEC: 5.0 microg/l
48h LOEC: 16.0 microg/l
48h IC50: 9.5 microg/l (95% confidence range: 7.5 - 10.5 microg/l)
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