Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-643-2 | CAS number: 85566-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 5 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 6
- Details on results:
- Column 1
A column was prepared in a narrow bore glass pipette. A plug of glass wool (0.5ml) was placed at the bottom of the column followed by a base of clean dry sand. The exit tubing for the column was attached and fixed in a vertical position to prevent eluent outflow. The exit tubing for the column was attached and fixed in a vertical position to prevent eluent outflow. The tubing used in the column was clean and made of a good grade PET material.
A 10 g/l solution of sample was prepared weighing out 1.0018g of sample into a 100ml volumetric flask in DCM. 0.6054 g of clean dry sand was placed in a 100ml round bottomed flask and 50ml of 10g/l solution of sample was added to the sand. The flask was swirled to mix up the content and waited three days until all solvent had evaporated. After equilibration 0.927g of the sand and water was added to the column. The flask and funnel were rinsed with more water and then a further bed of clean sand was added with a final plug of glass wool on top. Tubing was attached to the top of the column and the system attached through more inert tubing to a peristaltic membrane pump to allow circulation of the eluent, the column was left to equilibrate at 20±1°C. After equilibration in order to get rid of all the bubbles, the pump was started and adjusted to give a flow rate of 25ml/hr. Subsequently the return/sampling tube was redirected to the reservoir to allow recirculation of the eluent. After 24 hours the efficiency of the set-up and also the presence of undissolved particles was checked. The system did not show any particles undissolved and therefore was considered
acceptable. After the first check a Sample of 1.5ml was then taken at 24 hour intervals and then transferred into 2ml GC vials and refrigerated prior to extraction and analysis (1A-10A). The pH of samples was measured (6.0) and the temperature was recorded (19.2-20.6ºC) at each sampling.
Column 2
A column was prepared in a narrow bore glass pipette. A plug of glass wool (0.5ml) was placed at the bottom of the column followed by a base of clean dry sand. The exit tubing for the column was attached and fixed in a vertical position to prevent eluent outflow. The exit tubing for the column was attached and fixed in a vertical position to prevent eluent outflow. The tubing used in the column was clean and made of a good grade PET material. A 10 g/l solution of Sample was prepared weighing out 1.0018g of sample into a 100ml volumetric flask in DCM. 0.6085 g of clean dry sand was placed in a 100ml round bottomed flask and 50ml of 10g/l solution of sample was added to the sand. The flask was swirled to mix up the content and waited three days until all solvent had evaporated. After equilibration 0.9527 g of the sand and water was added to the column. The flask and funnel were rinsed with more water and then a further bed of clean sand was added with a final plug of glass wool on top. Tubing was attached to the top of the column and the system attached through more inert tubing to a peristaltic membrane pump to allow circulation of the eluent, the column was left to equilibrate at 20°C±1 . After equilibration in order to get rid of all the bubbles, the pump was started and adjusted to give a flow rate of 12.5 ml/hr. Subsequently the return/sampling tube was redirected to the reservoir to allow recirculation of the eluent. After 24 hours the efficiency of the set-up and also the presence of undissolved particles was checked. The system did not show any particles undissolved and therefore was considered acceptable.
After the first check a Sample of 1.5ml was then taken at 24 hour intervals and then transferred into 2ml GC vials and refrigerated prior to extraction and analysis (1B-10B). The pH of samples was measured (6.0) and the temperature was recorded (19.2-20.6ºC) at each sampling. - Conclusions:
- No peak was detected in these samples and therefore the sample solubility in water was found to be < 5mg/L (LOD) at 20 ± 0.4 °C using the column elution method.
- Executive summary:
The water solubility of fatty acids, C16 -18, reaction with ethanolamine, was evaluated in accordance with the OECD Testing Guideline 105. Following a preliminary test, a column elution method was performed and two columns were used, with 10 samples each.
The protocol states that for each run, the mean value and standard deviation from at least five consecutive samples taken from the saturation plateau should be calculated. The mean values obtained from two tests with different flows should not differ by more than 30%.
The samples 2, 3, 4, 5 and 6 from Column 1 were considered for the calculations of the average and the standard deviation.
The samples 2, 3, 4, 5 and 6 from Column 2 were considered for the calculations of the average and the standard deviation.
Also, the average value of the temperatures recorded at sampling 2,3,4,5 and 6 were 19.7°C for the minimum and 20.0°C for the maximum, therefore the final solubility reported at 20± 0.4 °C.
No peak was detected in these samples and therefore the sample solubility in H2O was found to be < 5mg/L (LOD) at 20 ± 0.4 °C using the column elution method.
The difference between the mean values from the Column 1 and the Column 2 are within ≤30%.
There was no evidence of chemical instability seen during this study.
Reference
The protocol states that for each run, the mean value and standard deviation from at least five consecutive samples taken from the saturation plateau should be calculated. The mean values obtained from two tests with different flows should not differ by more than 30%.
The samples 2, 3, 4, 5 and 6 from Column 1 were considered for the calculations of the average and the standard deviation.
The samples 2, 3, 4, 5 and 6 from Column 2 were considered for the calculations of the average and the standard deviation.
Also, the average value of the temperatures recorded at sampling 2,3,4,5 and 6 were 19.7°C for the minimum and 20.0°C for the maximum, therefore the final solubility reported at 20± 0.4 °C.
No peak was detected in these samples and therefore the sample solubility in H2O
was found to be < 5mg/l(LOD) at 20 ± 0.4 °C using the column elution method.
The difference between the mean values from the Column 1 and the Column 2 are within ≤30%.
There was no evidence of chemical instability seen during this study.
Description of key information
The water solubility of fatty acids, C16 -18, reaction with ethanolamine, was evaluated in accordance with the OECD Testing Guideline 105. Following a preliminary test, a column elution method was performed and two columns were used, with 10 samples each.
The protocol states that for each run, the mean value and standard deviation from at least five consecutive samples taken from the saturation plateau should be calculated. The mean values obtained from two tests with different flows should not differ by more than 30%.
The samples 2, 3, 4, 5 and 6 from Column 1 were considered for the calculations of the average and the standard deviation.
The samples 2, 3, 4, 5 and 6 from Column 2 were considered for the calculations of the average and the standard deviation.
Also, the average value of the temperatures recorded at sampling 2,3,4,5 and 6 were 19.7°C for the minimum and 20.0°C for the maximum, therefore the final solubility reported at 20± 0.4 °C.
No peak was detected in these samples and therefore the sample solubility in H2O was found to be < 5mg/L (LOD) at 20 ± 0.4 °C using the column elution method.
The difference between the mean values from the Column 1 and the Column 2 are within ≤30%.
There was no evidence of chemical instability seen during this study.
Key value for chemical safety assessment
- Water solubility:
- 5 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.