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EC number: 855-027-8 | CAS number: 2409921-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 27, 2019 to July 15, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Dihua sewage treatment plant, Taiwan.
- Duration of test (contact time):
- 29 d
- Initial conc.:
- 20 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- 1. Before the study starting, prepared inoculum in medium was aerated with CO2-free air for one day.
2. Test grouping:
2.1 Test group: Contain the test article, inoculum and medium. It was conducted with two replicates. In the test, test article (TOC concentration was 21.50%) was added, and total volume was 1.2 L. Final concentration of TOC was 20.00 mg/L.
2.2 Control group: Only contain inoculum and medium. It was conducted with two replicates.
2.3 Reference group: Contain the reference article, inoculum and medium. It was conducted with one replicate. In the test, 4.00g/L reference article (TOC concentration was 29.26%) was added, and total volume was 1.2 L. Final concentration of TOC was 20.00 mg/L.
2.4 Toxicity group: Contain the test article, reference article, inoculum and medium. Total volume was 1.2 L. It was conducted with one replicate. Test article and 4.00 g/L reference article were added, and total volume was 1.2 L. Final concentration of TOC was 40.00 mg/L. (Test article concentration of TOC was 20.00 mg/L and reference article concentration of TOC was 20.00 mg/L).
3. Three absorption bottles, each filled with 0.0125 M barium hydroxide solution of 100mL as CO2 absorbent, were connected in series to each culture flask.
4. Each group was aerated with CO2-free air at rate of 60±10 mL/min. CO2 production was measured on day 2, 5, 7, 9, 14, 19, 23, 28 and 29.
5. During the measurement, an absorption bottle closest to the culture flask was disconnected. The remaining two bottles were moved closer accordingly, followed by a new bottle at the end. The disconnected bottle with phenolphthalein as the indicator was titrated with 0.05 M HCl to determine CO2 production.
6. On day 28, 1.00 mL of concentrated hydrochloric acid (36.5~38%) was added into each culture flask and aerated with CO2-free air for overnight. Level of CO2 production was measured on day 29. - Reference substance:
- acetic acid, sodium salt
- Remarks:
- Sodium acetate
- Test performance:
- In the test, difference of percentage biodegradation between two replicate of test group were all less than 20.00%. The test was in compliance with validity of the test.
At the end of the test, average cumulative CO2 production of the control group was 66.00 mg/L, which was obviously lower than 70.00 mg/L. This suggested that the test was in compliance with validity of the test
On day 9, percentage biodegradation of the reference article was greater than 60.00%. The test was compliance with validity of the test. - Parameter:
- % degradation (CO2 evolution)
- Value:
- < 60
- Sampling time:
- 29 d
- Details on results:
- In the study, average percentage biodegradation (% ThCO2) of test groups were 1.06%, 0.87%, -0.19%, -1.00%, -2.81%, -5.37%, -7.30%, -9.98% and -11.79% on day 2, 5, 7, 9, 14, 19, 23, 28 and 29, respectively.
Percentage biodegradation (% ThCO2) of the reference group were 21.73%, 46.95%, 59.43%, 66.30%, 72.79%, 76.29%, 77.73%, 77.48% and 78.41% on day 2, 5, 7, 9, 14, 19, 23, 28 and 29, respectively.
Percentage biodegradation (% ThCO2) of the toxicity group were 11.17%, 23.27%, 29.90%, 32.83%, 52.02%, 35.20%, 34.49%, 33.05% and 32.21% on day 2, 5, 7, 9, 14, 19, 23, 28 and 29, respectively.
The pH of all groups on day 0, 28 and 29 were range between 7.62~7.67, 7.58~8.57 and 2.05~2.21. - Results with reference substance:
- At Day 14 during the study, the biodegradation was 72.79 %.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- According to OECD 301B test method, CR SB33 was not be considered readily biodegradable.
- Executive summary:
This test using the procedures outlined in the SuperLab Study Plan for MZ6-181200029 which is based on the SOP for the OECD 301B (SOPE-503) and OECD 301B (OECD, 1992). The results of this OECD 301B test for CR SB33 show that all validity criteria were met. CR SB33 can not be considered readily biodegradable under the test conditions and the percentage biodegradation of CR SB33 in sludge was less than 60 %.
Reference
Table 1. The CO2 production of control group, test group, reference group and toxicity group
Time (Day) |
Control group (mg) (1) (2) Mean |
Test group (mg) (1) (2) |
Reference group (mg) |
Toxicity group (mg) |
|||
2 | 5.39 | 4.51 | 4.95 | 6.49 | 5.28 | 24.09 | 24.64 |
5 | 7.70 | 7.92 | 7.81 | 8.69 | 6.60 | 30.03 | 29.15 |
7 | 5.61 | 7.37 | 6.49 | 6.27 | 4.84 | 17.49 | 18.15 |
9 | 4.29 | 5.17 | 4.73 | 4.29 | 3.74 | 10.78 | 9.90 |
14 | 7.70 | 10.34 | 9.02 | 7.81 | 7.04 | 14.74 | 12.87 |
19 | 9.90 | 11.88 | 10.89 | 9.13 | 8.14 | 13.97 | 11.22 |
23 | 10.78 | 12.65 | 11.72 | 10.45 | 9.57 | 12.98 | 10.45 |
28 | 11.00 | 12.98 | 11.99 | 10.12 | 9.13 | 11.77 | 9.46 |
29 | 10.67 | 12.54 | 11.61 | 10.67 | 9.35 | 12.43 | 10.12 |
Table 2. The cumulative CO2production and percentage biodegradation of control group, test group, reference control and toxicity group
Time (Day) |
Cumulative CO2production (mg) Control group (mg) Test group (mg) Reference Toxicity Mean (1) (2) group group |
Percentage b odegradation (% ThCO2) Test group (mg) Reference Toxicity Mean (1) (2) group group |
||||||||
2 |
4.95 |
1.54 |
0.33 |
19.14 |
19.69 |
1.75 |
0.37 |
1.06 |
21.73 |
11.17 |
5 |
12.76 |
2.42 |
-0.88 |
41.36 |
41.03 |
2.75 |
-1.00 |
0.87 |
46.95 |
23.28 |
7 |
19.25 |
2.20 |
-2.53 |
52.36 |
52.69 |
2.50 |
-2.87 |
-0.19 |
59.43 |
29.90 |
9 |
23.98 |
1.76 |
-3.52 |
58.41 |
57.86 |
2.00 |
-3.99 |
-1.00 |
66.30 |
32.83 |
14 |
33.00 |
0.55 |
-5.50 |
64.13 |
61.71 |
0.62 |
-6.24 | -2.81 | 72.79 | 35.02 |
19 | 43.89 | -1.21 | -8.25 | 67.21 | 62.04 | -1.37 | -9.36 | -5.37 | 76.29 | 35.20 |
23 | 55.61 | -2.48 | -10.40 | 68.48 | 60.78 | -2.81 | -11.79 | -7.30 | 77.73 | 34.49 |
28 | 67.60 | -4.35 | -13.26 | 68.26 | 58.25 | -4.93 | -15.04 | -9.98 | 77.48 | 33.05 |
29 | 79.20 | -5.28 | -15.51 | 69.08 | 56.76 | -5.99 | -17.60 | -11.79 | 78.41 | 32.21 |
Description of key information
Not readily biodegradable (OECD TG 301B).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
According to analysis of total organic carbon, TOC result of CR SB33 was 214,950 mg/kg. Therefore, the TOC concentration of CR SB33 was 21.50%. Difference of percentage biodegradation between two replicate of test group were all less than 20.00%. The test was in compliance with validity of the test. Average cumulative CO2 production of the control group was 66.00 mg/L, which was obviously lower than 70.00 mg/L. This suggested that the test was in compliance with validity of the test. On Day 9, percentage biodegradation of the reference article was greater than 60.00%. The test was compliance with validity of the test. Percentage biodegradation (% ThCO2) of CR SB33 were all <60.00%. Therefore, CR SB33 was not the readily biodegradable article.
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