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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 March 2018 to 09 April 2018
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test item is listed as ATHC (CAS # 24817-92-3) and is pale yellow slightly viscous liquid obtained from the Sponsor, Vertellus, with 99.4% purity and stored at room temperature in the dark.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- The test was carried out using juvenile rainbow trout (Oncorhynchus mykiss). Fish were obtained from Brow Well Fisheries Limited, Hebden, near Skipton, Yorkshire, UK and maintained in-house since 09 March 2018. Fish were maintained in a glass fiber tank with a "single pass" water renewal system. Fish were acclimatized to test conditions from 19 March 2018 to 26 March 2018. The lighting cycle was controlled to give a 16 hours light and 8 hours darkness cycle with 20 minute dawn and dusk transition periods.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- test water was partly softened giving water a total hardness of 140 mg CaCO3/L
- Test temperature:
- water temperature of 14 ˚C to 15 ˚C
- pH:
- 7.1 to 8.2
- Dissolved oxygen:
- 9.3 mg O2/L to 11.6 O2/L
- Nominal and measured concentrations:
- A preliminary media preparation trial indicated that a saturated solution method of preparation was appropriate for this test item. Based on the results of the range-finding test a limit test was conducted at a concentration of 100% v/v saturated solution which corresponds to an initial loading rate 50 mg/L.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- Test solution prepared with a loading rate of 50 mg/L resulting in a 100% v/v saturation solution.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 other: % v/v saturated solution
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- 100% v/v saturated solution prepared from a test solution with a loading rate of 50 mg/L.
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 50 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- Test solution prepared with a loading rate of 50 mg/L resulting in a 100% v/v saturation solution.
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 other: % v/v saturated solution.
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- 100% v/v saturated solution prepared from a test solution with a loading rate of 50 mg/L.
- Validity criteria fulfilled:
- yes
- Remarks:
- Control mortality 0 fish (protocol ≤ 10 %); Dissolved O2 above 60% (protocol >60%); pH 7.1 to 8.2 (protocol not vary > 1 unit).
- Conclusions:
- The test substance did not cause toxic effects to the freshwater fish rainbow trout (Oncorhynchus mykiss) in a limit test with a 100% v/v saturated solution after 96 h of exposure; therefore, there were no toxic effects at saturation. The effects concentrations were based on the nominal test concentration of 100% v/v saturated solution which was equivalent to an initial nominal loading rate of 50 mg/L. The effects concentrations were reported both as 48-h LC50 > 100% v/v saturated solution and 48-h EL50 >50 mg/L. The no effects concentrations were reported both as 48-h NOEC of 100% v/v saturated solution and 48-h NOELR of 50 mg/L.
Reference
Description of key information
The key study was a semi-static acute fish toxicity test on the effects of the test substance on the freshwater rainbow trout (Oncorhynchus mykiss) following OECD Guideline 203. The test substance did not cause toxic effects to the test organism in a limit test with a 100% v/v saturated solution after 96 h of exposure; therefore, there were no toxic effects at saturation. The effects concentrations were based on the nominal test concentration of 100% v/v saturated solution which was equivalent to an initial nominal loading rate of 50 mg/L. The effects concentrations were reported both as 48-h LC50 > 100% v/v saturated solution and 48-h EL50 >50 mg/L. The no effects concentrations were reported both as 48-h NOEC of 100% v/v saturated solution and 48-h NOELR of 50 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 50 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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