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EC number: 500-013-6 | CAS number: 9004-78-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/10/2019 - 03/10/2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Conducted in a GLP compliant laboratory but not as part of a formal GLP study.
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. -0.12 - ca. -0.11
- Temp.:
- 21.6 °C
- pH:
- 8
- Type:
- log Pow
- Partition coefficient:
- ca. -1.07 - ca. -1.02
- Temp.:
- 21.6 °C
- pH:
- 8
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.07 - ca. -0.11
- Temp.:
- 21.6 °C
- pH:
- 8
- Details on results:
- 1 peak was detected with UV and 2 with RI. The log Pow values range from -1.07 to -0.11. These results show all detected peaks have log Pow values less than 3.0 and are consistent with a material that has little tendency to accumulate in the environment. Phenol, ethoxylated was found to be miscible in 75:25 MeOH: pH8.0 buffer mobile phase which was injected directly onto the column and then run with 75:25 MeOH: pH8.0 buffer mobile phase.
- Conclusions:
- The partition coefficient range for Phenol, ethoxylated was determined to be from -1.07 to -0.11.
- Executive summary:
The partition coefficient of Phenol, ethoxylated was determined using the HPLC method, designed to be compatible with Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. Phenol, ethoxylated was found to be miscible in 75:25 MeOH: pH 8.0 buffer mobile phase. The test material was injected onto the column of a High-Performance Liquid Chromatograph (HPLC) and then run with 75:25 MeOH: pH 8.0 buffer mobile phase. The relationship between the retention time of the material(s) and the n-octanol/water partition coefficient enabled the bioaccumulation potential of the test sample to be established. The partition coefficient was derived from the capacity factor k given by the expression: k= tR-t0/t0. Where: tR is the retention time of the test material (or a component) and t0 is the dead-time. Calibration graphs were generated for log k against log Pow (the partition coefficient), for the reference compounds, for both RI and UV detectors. As the capacity factor for the first peak was negative the log Pow could not be calculated. 1 peak was detected with UV and 2 peaks were detected with RI. The log Pow values for the attained peaks ranged from -1.07 to -0.11. The validity criteria states that the calibration standards (both UV and RI) should have R2 values greater than 0.95 and that the variation between test replicate peaks should be less than or equal to ±0.1 log units. Both these conditions were met for this test. Results showed that all detected peaks have log Pow values less than 3.0 and are consistent with a material that has little tendency to accumulate in the environment. Therefore, based on these findings the partition coefficient range for Phenol, ethoxylated was determined to be from -1.07 to -0.11.
Reference
The validity criteria states that the calibration standards (both UV and RI) should have R2 values greater than 0.95 and that the variation between test replicate peaks should be less than or equal to ±0.1 log units. Both these conditions were met for this test.
Description of key information
The partition coefficient of Phenol, ethoxylated was determined using the HPLC method, designed to be compatible with Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. Phenol, ethoxylated was found to be miscible in 75:25 MeOH: pH 8.0 buffer mobile phase. The test material was injected onto the column of a High-Performance Liquid Chromatograph (HPLC) and then run with 75:25 MeOH: pH 8.0 buffer mobile phase. The relationship between the retention time of the material(s) and the n-octanol/water partition coefficient enabled the bioaccumulation potential of the test sample to be established. The partition coefficient was derived from the capacity factor k given by the expression: k= tR-t0/t0. Where: tR is the retention time of the test material (or a component) and t0 is the dead-time. Calibration graphs were generated for log k against log Pow (the partition coefficient), for the reference compounds, for both RI and UV detectors. As the capacity factor for the first peak was negative the log Pow could not be calculated. 1 peak was detected with UV and 2 peaks were detected with RI. The log Pow values for the attained peaks ranged from -1.07 to -0.11. The validity criteria states that the calibration standards (both UV and RI) should have R2 values greater than 0.95 and that the variation between test replicate peaks should be less than or equal to ±0.1 log units. Both these conditions were met for this test. Results showed that all detected peaks have log Pow values less than 3.0 and are consistent with a material that has little tendency to accumulate in the environment. Therefore, based on these findings the partition coefficient range for Phenol, ethoxylated was determined to be from -1.07 to -0.11.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.11
- at the temperature of:
- 21.6 °C
Additional information
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