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EC number: 444-810-6
CAS number: -
A study was performed to assess the eye irritation potential of
CP-163,625-BV to the rabbit. The method followed was that described in
the following guidelines: EEC Methods for the determination of toxicity,
Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method
B.5. Acute toxicity (eye irritation). OECD Guideline for the Testing of
Chemicals No. 405. "Acute Eye Irritation/Corrosion", Adopted 24 February
1987. One rabbit was administered a single ocular dose of a volume of
0.1 ml (approximately 43 g) of the test substance, and observed for 3
days after instillation. Due to the severity of the reactions seen, one
animal only was used. A single instillation of CP-163,625-BV into the
eye of the rabbit elicited corneal opacification with iridial
inflammation and severe conjunctival irritation. Due to the severity of
the reactions CP-163,625-BV will require labelling with the risk phrase
R41, "Risk of serious damage to eyes", in accordance with Commission
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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